These authors contributed equally.
Biodegradable Gold Nanovesicles with an Ultrastrong Plasmonic Coupling Effect for Photoacoustic Imaging and Photothermal Therapy†
Article first published online: 6 DEC 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 52, pages 13958–13964, December 23, 2013
How to Cite
Huang, P., Lin, J., Li, W., Rong, P., Wang, Z., Wang, S., Wang, X., Sun, X., Aronova, M., Niu, G., Leapman, R. D., Nie, Z. and Chen, X. (2013), Biodegradable Gold Nanovesicles with an Ultrastrong Plasmonic Coupling Effect for Photoacoustic Imaging and Photothermal Therapy. Angew. Chem. Int. Ed., 52: 13958–13964. doi: 10.1002/anie.201308986
This research was supported by the startup funds of the University of Maryland, the Intramural Research Program (IRP) of the NIBIB, the NIH, the National Key Basic Research Program (973 Project; 2010CB933901, 2013CB733802, 2014CB744503), the National Science Foundation of China (81272987, 31170961, 51102258, 81371596), and a Chinese Academy of Sciences Professorship for Senior International Scientists (2011T2J06).
- Issue published online: 18 DEC 2013
- Article first published online: 6 DEC 2013
- Manuscript Revised: 11 NOV 2013
- Manuscript Received: 15 OCT 2013
- University of Maryland
- Intramural Research Program (IRP) of the NIBIB
- National Key Basic Research Program (973 Project;. Grant Numbers: 2010CB933901, 2013CB733802, 2014CB744503
- National Science Foundation of China. Grant Numbers: 81272987, 31170961, 51102258, 81371596
- Chinese Academy of Sciences Professorship for Senior International Scientists. Grant Number: 2011T2J06
- biodegradable block copolymers;
- gold nanovesicles;
- photoacoustic imaging;
- photothermal therapy;
- plasmonic coupling
The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered to the near-infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) imaging and PTT. The disulfide bond at the terminus of a PEG-b-PCL block-copolymer graft enables dense packing of GNPs during the assembly process and induces ultrastrong plasmonic coupling between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η=37 %) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with improved clearance of the dissociated particles after the completion of PTT. The assembly of various nanocrystals with tailored optical, magnetic, and electronic properties into vesicle architectures opens new possibilities for the construction of multifunctional biodegradable platforms for biomedical applications.