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Inside Cover: A Chemical Perspective on Transcriptional Fidelity: Dominant Contributions of Sugar Integrity Revealed by Unlocked Nucleic Acids (Angew. Chem. Int. Ed. 47/2013)

Authors

  • Dr. Liang Xu,

    1. Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego, La Jolla, CA 92093-0625 (USA)
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    • These authors contributed equally to this work.

  • Steven W. Plouffe,

    1. Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego, La Jolla, CA 92093-0625 (USA)
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    • These authors contributed equally to this work.

  • Jenny Chong,

    1. Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego, La Jolla, CA 92093-0625 (USA)
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  • Prof. Dr. Jesper Wengel,

    1. Nucleic Acid Center and Biomolecular Nanoscale Engineering Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M (Denmark)
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  • Prof. Dr. Dong Wang

    Corresponding author
    1. Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego, La Jolla, CA 92093-0625 (USA)
    • Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego, La Jolla, CA 92093-0625 (USA)

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Abstract

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An acyclic synthetic RNA analogue was used to reveal the important role of the nucleotide sugar ring in transcriptional fidelity. In their Communication on page 12341 ff., D. Wang et al. demonstrate that the contribution of the intact nucleotide sugar backbone to the enzymatic efficiency and transcriptional fidelity of RNA polymerase II is significantly stronger than that of the other functional groups of the nucleotide, including the nucleobase and ribose 2′-OH group.

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