This work was supported by Fundación Ramón Areces (R.F.M.) and by the Leverhulme Trust (G.W.J.F.).
Short and Sweet: D-Glucose to L-Glucose and L-Glucuronic Acid†
Article first published online: 5 DEC 2013
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 53, Issue 4, pages 1160–1162, January 20, 2014
How to Cite
Martínez, R. F., Liu, Z., Glawar, A. F. G., Yoshihara, A., Izumori, K., Fleet, G. W. J. and Jenkinson, S. F. (2014), Short and Sweet: D-Glucose to L-Glucose and L-Glucuronic Acid. Angew. Chem. Int. Ed., 53: 1160–1162. doi: 10.1002/anie.201309073
- Issue published online: 21 JAN 2014
- Article first published online: 5 DEC 2013
- Manuscript Received: 17 OCT 2013
- Fundación Ramón Areces
- Leverhulme Trust
- organic synthesis;
- rare sugars
The scarcity and expense of access to L-sugars and other rare sugars have prevented the exploitation of their biological potential; for example D-psicose, only recently available, has been recognized as an important new food. Here we give the definitive and cheap synthesis of 99.4% pure L-glucose from D-glucose which requires purification of neither intermediates nor final product other than extraction into and removal of solvents; a simple crystallization will raise the purity to >99.8%.