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Synthesis of the C18-Norditerpenoid Alkaloid Neofinaconitine: A Lesson in Convergent Synthesis Planning

Authors

  • Dr. Xiao-Yu Liu,

    1. Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (South Korea)
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  • Prof. Dr. David Y.-K. Chen

    Corresponding author
    1. Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (South Korea)
    • Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (South Korea)

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Abstract

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Hexacyclic framework: The total synthesis of the complex C18-norditerpenoid alkaloid neofinaconitine has been achieved by a convergent approach. This remarkable synthesis featured two Diels–Alder cycloadditions and subsequent Mannich-type N-acyliminium and radical cyclizations to establish the unique hexacyclic core structure of the target molecule.

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