Inside Back Cover: Structure-Based Design of an RNA-Binding p-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function (Angew. Chem. Int. Ed. 50/2013)

Authors

  • Luis González-Bulnes,

    1. Universidad Católica de Valencia, C/Quevedo 2, 46001 Valencia (Spain)
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    • These authors contributed equally to this work.

  • Ignacio Ibáñez,

    1. Universidad de Valencia, Avda. V. A. Estellés s/n, 46100 Burjassot (Spain)
    2. Centro de Investigación Príncipe Felipe, Avda. Autopista del Saler 16, 46012 Valencia (Spain)
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    • These authors contributed equally to this work.

  • Dr. Luis M. Bedoya,

    1. Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo km 2, 28220 Majadahonda (Spain)
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  • Manuela Beltrán,

    1. Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo km 2, 28220 Majadahonda (Spain)
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  • Dr. Silvia Catalán,

    1. Universidad de Valencia, Avda. V. A. Estellés s/n, 46100 Burjassot (Spain)
    2. Centro de Investigación Príncipe Felipe, Avda. Autopista del Saler 16, 46012 Valencia (Spain)
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  • Dr. José Alcamí,

    Corresponding author
    1. Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo km 2, 28220 Majadahonda (Spain)
    • José Alcamí, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo km 2, 28220 Majadahonda (Spain)===

      Santos Fustero, Universidad de Valencia, Avda. V. A. Estellés s/n, 46100 Burjassot (Spain)===

      José Gallego, Universidad Católica de Valencia, C/Quevedo 2, 46001 Valencia (Spain)===

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  • Prof. Santos Fustero,

    Corresponding author
    1. Universidad de Valencia, Avda. V. A. Estellés s/n, 46100 Burjassot (Spain)
    2. Centro de Investigación Príncipe Felipe, Avda. Autopista del Saler 16, 46012 Valencia (Spain)
    • José Alcamí, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo km 2, 28220 Majadahonda (Spain)===

      Santos Fustero, Universidad de Valencia, Avda. V. A. Estellés s/n, 46100 Burjassot (Spain)===

      José Gallego, Universidad Católica de Valencia, C/Quevedo 2, 46001 Valencia (Spain)===

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  • Dr. José Gallego

    Corresponding author
    1. Universidad Católica de Valencia, C/Quevedo 2, 46001 Valencia (Spain)
    • José Alcamí, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo km 2, 28220 Majadahonda (Spain)===

      Santos Fustero, Universidad de Valencia, Avda. V. A. Estellés s/n, 46100 Burjassot (Spain)===

      José Gallego, Universidad Católica de Valencia, C/Quevedo 2, 46001 Valencia (Spain)===

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Abstract

original image

Bilaterally substituted p-terphenyl molecules reproduce the interactions of an α-helix of the HIV-1 protein Rev with its RNA receptor and block Rev function and virus replication. In their Communication on page 13405 ff., J. Alcamí, S. Fustero, and J. Gallego et al. report the structure-based design of p-terphenyl molecules that inhibit the Rev-mediated transport of HIV-1 RNA from the nucleus to the cytoplasm by binding to the RNA loop that is recognized by Rev (image prepared with the help of M.C. Ibáñez).

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