Aerobic Oxidation in Nanomicelles of Aryl Alkynes, in Water at Room Temperature


  • Financial support for this work was provided by the U.S. National Institutes of Health (GM 86485). We thank Shane Rainey for technical assistance.


On the basis of the far higher solubility of oxygen gas inside the hydrocarbon core of nanomicelles, metal and peroxide free aerobic oxidation of aryl alkynes to β-ketosulfones has been achieved in water at room temperature. Many examples are offered that illustrate broad functional group tolerance. The overall process is environmentally friendly, documented by the associated low E Factors.