• Alzheimer’s disease;
  • dementia;
  • drug discovery;
  • neurodegenerative disease;
  • total synthesis

The human brain is an incredibly complex network of neurons that controls life, thoughts, and emotion. Age- or disease-related neural degeneration leads to breakdown of this network, incapacitating the affected individual. Certain natural products can induce outgrowth of neurites, the bridges that allow cell–cell communication in the brain, and so restore the neuronal web. E. A. Theodorakis et al. summarize in their Review on page 956 ff. recent advances in the synthesis of these molecules and highlight their potential as tools for studying neuronal web structure and function.

Affinity Pairs

In their Communication on page 988 ff., K. Mlinarić-Majerski, R. Glaser, L. Isaacs, et al. report the formation of an exceptionally tight noncovalent complex between cucurbit[7]uril and a diamantane diammonium ion in pure D2O.

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A cobalt-containing zeolitic imidazolate framework that functions as a co-catalyst for the reduction of CO2 in the presence of a ruthenium photosensitizer is described by X. Wang and co-workers in their Communication on page 1034 ff.

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Dynamic Porous Materials

P. Sozzani et al. demonstrate in their Communication on page 1043 ff., that low-density, yet robust covalent architectures can sustain extremely rapid rotational motion of phenylene rings.

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