Remote Stereocontrol Transmitted through Helicity


  • We thank the European Research Council (grant agreement no. 259056 to M.D.S.) and EPSRC and Pfizer (industrial CASE award to C.P.J.).


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Near…far…wherever you are! Two chiral residues at the N-terminus of a helical foldamer are sufficient to induce a significant helical screw-sense preference. The capacity of this helix to transmit stereochemical information is exemplified by highly stereoselective transformations conducted over nanometer distances.