Bio-Inspired Photonic-Crystal Microchip for Fluorescent Ultratrace Detection

Authors

  • Dr. Jue Hou,

    1. Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn
    2. University of Chinese Academy of Sciences, Beijing (P. R. China)
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  • Dr. Huacheng Zhang,

    1. Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn
    2. University of Chinese Academy of Sciences, Beijing (P. R. China)
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  • Dr. Qiang Yang,

    1. Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn
    2. University of Chinese Academy of Sciences, Beijing (P. R. China)
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  • Prof. Dr. Mingzhu Li,

    Corresponding author
    1. Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn
    • Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn===

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  • Prof. Dr. Yanlin Song,

    Corresponding author
    1. Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn
    • Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn===

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  • Prof. Dr. Lei Jiang

    1. Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn
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  • M.L. and Y.S. gratefully acknowledge financial support from the NSFC (grant numbers 51173190, 21003132, 91127038, and 21121001), the 973 Program (grant numbers 2013CB933004, 2011CB932303, and 2011CB808400), Beijing Nova Program (grant number Z131103000413051), and the “Strategic Priority Research Program” of the Chinese Academy of Sciences (grant number XDA09020000).

Abstract

Ultratrace detection attracts great interest because it is still a challenge to the early diagnosis and drug testing. Enriching the targets from highly diluted solutions to the sensitive area is a promising method. Inspired by the fog-collecting structure on Stenocara beetle’s back, a photonic-crystal (PC) microchip with hydrophilic–hydrophobic micropattern was fabricated by inkjet printing. This device was used to realize high-sensitive ultratrace detection of fluorescence analytes and fluorophore-based assays. Coupled with the fluorescence enhancement effect of a PC, detection down to 10−16 mol L−1 was achieved. This design can be combined with biophotonic devices for the detection of drugs, diseases, and pollutions of the ecosystem.

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