Back Cover: Yoctoliter Thermometry for Single-Molecule Investigations: A Generic Bead-on-a-Tip Temperature-Control Module (Angew. Chem. Int. Ed. 13/2014)



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By focusing a low-intensity laser on black microbeads, a large temperature jump can be achieved within milliseconds, as described by H. Mao and co-workers in their Communication on page 3470 ff. The temperature variation in a yoctoliter volume was measured by exploiting the mechanochemical properties of individual DNA hairpins.

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