Using two-photon absorption ruthenium complexes that bind to nuclear DNA in fixed or living cells can be photoexcited within the biological optical window. In their Communication on page 3367 ff., J. A. Thomas and co-workers show that the long-lived 3MLCT emission of these “light-switch” complexes (>100 ns) means that they are also phosphorescence lifetime imaging microscopy (PLIM) probes.
In their Communication on page 3336 ff., L. Cronin et al. describe the incorporation of polyoxometalates (POMs) into peptides, which was achieved by the use of activated precursors and either a solution- or a solid-phase method.
A S. Ulrich, I V. Komarov, and co-workers report a photoswitchable analogue of the cyclic antimicrobial peptide gramicidin S based on a reversibly photoisomerizable diarylethene scaffold in their Communication on page 3392 ff.
In their Communication on page 3470 ff., H. Mao et al. describe how the temperature variation in a yoctoliter volume can be measured by exploiting the mechanochemical properties of individual DNA hairpins.