Cover Picture: An Efficient and Modular Route to Sequence-Defined Polymers Appended to DNA (Angew. Chem. Int. Ed. 18/2014)

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Abstract

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Sequence-controlled polymers attached to DNA can be prepared by solid-phase phosphoramidite coupling, as H. F. Sleiman, C. J. Serpell, and co-workers report in their Communication on page 4567 ff. Polymers with the same molecular composition but different monomer patterns exhibit different amphiphilic self-assembly. As the DNA component still retains base-pairing fidelity, these novel conjugates encode information in two distinct, and orthogonal, assembly languages.

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