Cover Picture: A New Pathway of DNA G-Quadruplex Formation (Angew. Chem. Int. Ed. 19/2014)

Authors

  • Dr. Slavko Čeru,

    1. EN-FIST Center of Excellence, Trg OF 13, 1000 Ljubljana (Slovenia)
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  • Dr. Primož Šket,

    1. EN-FIST Center of Excellence, Trg OF 13, 1000 Ljubljana (Slovenia)
    2. Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, Ljubljana (Slovenia)
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  • Dr. Iztok Prislan,

    1. Faculty of Chemistry and Chemical Technology, Physical Chemistry, University of Ljubljana, Aškerčeva 5, Ljubljana (Slovenia)
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  • Prof. Dr. Jurij Lah,

    Corresponding author
    1. Faculty of Chemistry and Chemical Technology, Physical Chemistry, University of Ljubljana, Aškerčeva 5, Ljubljana (Slovenia)
    • Jurij Lah, Faculty of Chemistry and Chemical Technology, Physical Chemistry, University of Ljubljana, Aškerčeva 5, Ljubljana (Slovenia)===

      Janez Plavec, EN-FIST Center of Excellence, Trg OF 13, 1000 Ljubljana (Slovenia)===

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  • Prof. Dr. Janez Plavec

    Corresponding author
    1. EN-FIST Center of Excellence, Trg OF 13, 1000 Ljubljana (Slovenia)
    2. Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, Ljubljana (Slovenia)
    3. Faculty of Chemistry and Chemical Technology, Physical Chemistry, University of Ljubljana, Aškerčeva 5, Ljubljana (Slovenia)
    • Jurij Lah, Faculty of Chemistry and Chemical Technology, Physical Chemistry, University of Ljubljana, Aškerčeva 5, Ljubljana (Slovenia)===

      Janez Plavec, EN-FIST Center of Excellence, Trg OF 13, 1000 Ljubljana (Slovenia)===

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Abstract

original image

Guanine-rich DNA sequences can self-assemble into specific pre-organized DNA structures, where two-by-two guanine residues shown as “duets” are involved in GG N1-carbonyl symmetric base pairs. In their Communication on page 4881 ff., J. Lah, J. Plavec, and co-workers demonstrate the transition of these “duets” into guanine-quartets, presented as a “string quartet” when interacting with cations, such as potassium ions. This rearrangement consequently leads to formation of G-quadruplex structures.

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