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In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites

Authors

  • Prof. Dr. Yi-Xiang J. Wang,

    Corresponding author
    1. Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China)
    • Yi-Xiang J. Wang, Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China)===

      Wei Wang, Department of Radiology, Xianya Third Hospital, Central South University, Changsha, Hunan (P. R. China)===

      Ken Cham-Fai Leung, Department of Chemistry, Institute of Creativity, and State Key Laboratory of Environmental and Biological Analysis, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR (P. R. China)===

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  • Dr. Xiao-Ming Zhu,

    1. Department of Chemistry, Institute of Creativity, and State Key Laboratory of Environmental and Biological Analysis, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR (P. R. China)
    2. Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China)
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  • Qi Liang,

    1. Department of Radiology, Xianya Third Hospital, Central South University, Changsha, Hunan (P. R. China)
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  • Prof. Dr. Christopher H. K. Cheng,

    1. School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China)
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  • Prof. Dr. Wei Wang,

    Corresponding author
    1. Department of Radiology, Xianya Third Hospital, Central South University, Changsha, Hunan (P. R. China)
    • Yi-Xiang J. Wang, Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China)===

      Wei Wang, Department of Radiology, Xianya Third Hospital, Central South University, Changsha, Hunan (P. R. China)===

      Ken Cham-Fai Leung, Department of Chemistry, Institute of Creativity, and State Key Laboratory of Environmental and Biological Analysis, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR (P. R. China)===

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  • Prof. Dr. Ken Cham-Fai Leung

    Corresponding author
    1. Department of Chemistry, Institute of Creativity, and State Key Laboratory of Environmental and Biological Analysis, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR (P. R. China)
    • Yi-Xiang J. Wang, Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China)===

      Wei Wang, Department of Radiology, Xianya Third Hospital, Central South University, Changsha, Hunan (P. R. China)===

      Ken Cham-Fai Leung, Department of Chemistry, Institute of Creativity, and State Key Laboratory of Environmental and Biological Analysis, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR (P. R. China)===

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  • This work was partially supported by Innovation Technology Fund (ITS/066/09) and RGC-General Research Fund (201213). Prof. Guo-liang Shao, Department of Radiology, Zhejiang Cancer Hospital is gratefully acknowledged.

Abstract

A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an in vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.

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