Get access

Double Trouble—The Art of Synthesis of Chiral Dimeric Natural Products

Authors

  • Tim Wezeman,

    1. Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany)
    Search for more papers by this author
  • Dr. Kye-Simeon Masters,

    Corresponding author
    1. Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology (QUT), GPO Box 2434, Brisbane, Queensland, 4001 (Australia)
    • Kye-Simeon Masters, Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology (QUT), GPO Box 2434, Brisbane, Queensland, 4001 (Australia)===

      Stefan Bräse, Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany)===

    Search for more papers by this author
  • Prof. Dr. Stefan Bräse

    Corresponding author
    1. Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany)
    2. Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen (Germany)
    • Kye-Simeon Masters, Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology (QUT), GPO Box 2434, Brisbane, Queensland, 4001 (Australia)===

      Stefan Bräse, Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany)===

    Search for more papers by this author

  • We acknowledge continuous funding through the DFG (BR 1750) and the Helmholtz Association. K.-S.M. acknowledges a Vice Chancellor’s Research Fellowship from QUT and T.W. acknowledges the Marie-Curie ITN ECHONET (grant no. 316379).

Abstract

original image

Double or nothing! Recently the total synthesis of secalonic acids A and D was reported. This work and other natural product syntheses with a dimerization step as a common feature are featured in this Highlight. The significant biological activity of the secalonic acids and the fact that their synthesis has fascinated synthetic chemists for the past forty years make this work a milestone in natural product synthesis.

Get access to the full text of this article

Ancillary