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Iron-Catalyzed 1,2-Addition of Perfluoroalkyl Iodides to Alkynes and Alkenes

Authors

  • Dr. Tao Xu,

    1. Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISCI-LSCI, BCH 3305, 1015 Lausanne (Switzerland) http://lsci.epfl.ch
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  • Dr. Chi Wai Cheung,

    1. Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISCI-LSCI, BCH 3305, 1015 Lausanne (Switzerland) http://lsci.epfl.ch
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  • Prof. Dr. Xile Hu

    Corresponding author
    1. Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISCI-LSCI, BCH 3305, 1015 Lausanne (Switzerland) http://lsci.epfl.ch
    • Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISCI-LSCI, BCH 3305, 1015 Lausanne (Switzerland) http://lsci.epfl.ch===

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  • This work is supported by a starting grant from the European Research Council (ERC), number 257096.

Abstract

Iron catalysis has been developed for the intermolecular 1,2-addition of perfluoroalkyl iodides to alkynes and alkenes. The catalysis has a wide substrate scope and high functional-group tolerance. A variety of perfluoroalkyl iodides including CF3I can be employed. The resulting perfluoroalkylated alkyl and alkenyl iodides can be further functionalized by cross-coupling reactions. This methodology provides a straightforward and streamlined access to perfluoroalkylated organic molecules.

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