R.V. is grateful to the DST for a Ramanujan Fellowship. We thank CSIR-NIIST for TEM experiments. We thank Dr. Subi J. George, JNCASR, for HR-MS analyses and Dr. Mahesh Hariharan for helpful discussion.
Self-Assembly of DNA–Oligo(p-phenylene-ethynylene) Hybrid Amphiphiles into Surface-Engineered Vesicles with Enhanced Emission†
Article first published online: 24 JUN 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 53, Issue 32, pages 8352–8357, August 4, 2014
How to Cite
Albert, S. K., Thelu, H. V. P., Golla, M., Krishnan, N., Chaudhary, S. and Varghese, R. (2014), Self-Assembly of DNA–Oligo(p-phenylene-ethynylene) Hybrid Amphiphiles into Surface-Engineered Vesicles with Enhanced Emission. Angew. Chem. Int. Ed., 53: 8352–8357. doi: 10.1002/anie.201403455
- Issue published online: 1 AUG 2014
- Article first published online: 24 JUN 2014
- Manuscript Revised: 19 MAY 2014
- Manuscript Received: 18 MAR 2014
- DNA nanotechnology;
- supramolecular chemistry;
Surface-addressable nanostructures of linearly π-conjugated molecules play a crucial role in the emerging field of nanoelectronics. Herein, by using DNA as the hydrophilic segment, we demonstrate a solid-phase “click” chemistry approach for the synthesis of a series of DNA–chromophore hybrid amphiphiles and report their reversible self-assembly into surface-engineered vesicles with enhanced emission. DNA-directed surface addressability of the vesicles was demonstrated through the integration of gold nanoparticles onto the surface of the vesicles by sequence-specific DNA hybridization. This system could be converted to a supramolecular light-harvesting antenna by integrating suitable FRET acceptors onto the surface of the nanostructures. The general nature of the synthesis, surface addressability, and biocompatibility of the resulting nanostructures offer great promises for nanoelectronics, energy, and biomedical applications.