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Copper-Catalyzed Borylative Allyl–Allyl Coupling Reaction


  • This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (“Organic synthesis based on reaction integration” and “Molecular activation directed toward straightforward synthesis”) from MEXT (Japan). K.S. is grateful to a Research Fellowship of JSPS for Young Scientists.


Borylative allyl–allyl coupling using allenes, bis(pinacolato)diboron, and allyl phosphates has been developed in the presence of a copper catalyst bearing an N-heterocyclic carbene ligand. The reaction affords boryl-substituted 1,5-diene derivatives in good to high yields with high regioselectivity and Z selectivity.