These authors contributed equally to this work.
Back Cover: Antagonizing STAT3 Dimerization with a Rhodium(III) Complex (Angew. Chem. Int. Ed. 35/2014)
Article first published online: 27 JUN 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 53, Issue 35, page 9390, August 25, 2014
How to Cite
Ma, D.-L., Liu, L.-J., Leung, K.-H., Chen, Y.-T., Zhong, H.-J., Chan, D. S.-H., Wang, H.-M. D. and Leung, C.-H. (2014), Back Cover: Antagonizing STAT3 Dimerization with a Rhodium(III) Complex (Angew. Chem. Int. Ed. 35/2014). Angew. Chem. Int. Ed., 53: 9390. doi: 10.1002/anie.201406152
- Issue published online: 21 AUG 2014
- Article first published online: 27 JUN 2014
- antitumor agents;
- protein–protein interactions;
STAT3 dimerization can be directly inhibited by a substitutionally inert, Group 9 organometallic compound, as D.-L. Ma, C.-H. Leung, H.-M. D. Wang, and co-workers report in their Communication on page 9178 ff. The cyclometalated rhodium(III) complex targets the SH2 domain of STAT3 (signal transducer and activator of transcription 3), and exhibits potent anticancer activity against melanoma xenograft in an in vivo mouse model.