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Keywords:

  • antitumor agents;
  • cytotoxicity;
  • dimerization;
  • protein–protein interactions;
  • rhodium
Thumbnail image of graphical abstract

STAT3 dimerization can be directly inhibited by a substitutionally inert, Group 9 organometallic compound, as D.-L. Ma, C.-H. Leung, H.-M. D. Wang, and co-workers report in their Communication on page 9178 ff. The cyclometalated rhodium(III) complex targets the SH2 domain of STAT3 (signal transducer and activator of transcription 3), and exhibits potent anticancer activity against melanoma xenograft in an in vivo mouse model.