Back Cover: Antagonizing STAT3 Dimerization with a Rhodium(III) Complex (Angew. Chem. Int. Ed. 35/2014)

Authors

  • Dr. Dik-Lung Ma,

    Corresponding author
    1. Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China)
    • Dik-Lung Ma, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China)

      Hui-Min David Wang, Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan (Republic of China)

      Chung-Hang Leung, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao (China)

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    • These authors contributed equally to this work.

  • Li-Juan Liu,

    1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao (China)
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  • Ka-Ho Leung,

    1. Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China)
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  • Yen-Ting Chen,

    1. Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan (Republic of China)
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  • Hai-Jing Zhong,

    1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao (China)
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  • Daniel Shiu-Hin Chan,

    1. Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China)
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  • Dr. Hui-Min David Wang,

    Corresponding author
    1. Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan (Republic of China)
    2. Graduate Institute of Natural Products, Kaohsiung Medical, University, Kaohsiung 807, Taiwan (Republic of China)
    • Dik-Lung Ma, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China)

      Hui-Min David Wang, Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan (Republic of China)

      Chung-Hang Leung, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao (China)

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  • Dr. Chung-Hang Leung

    Corresponding author
    1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao (China)
    • Dik-Lung Ma, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China)

      Hui-Min David Wang, Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan (Republic of China)

      Chung-Hang Leung, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao (China)

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    • These authors contributed equally to this work.


Abstract

original image

STAT3 dimerization can be directly inhibited by a substitutionally inert, Group 9 organometallic compound, as D.-L. Ma, C.-H. Leung, H.-M. D. Wang, and co-workers report in their Communication on page 9178 ff. The cyclometalated rhodium(III) complex targets the SH2 domain of STAT3 (signal transducer and activator of transcription 3), and exhibits potent anticancer activity against melanoma xenograft in an in vivo mouse model.

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