A.J.R.H. acknowledges continuous support to the Netherlands Proteomics Center by the Netherlands Organization for Scientific Research (NWO) supported large-scale proteomics facility Proteins@Work (project 184.032.201) and the PRIME-XS Project (Grant Agreement 262067) funded by the European Union Seventh Framework Program. J.M. is supported by Ramon y Cajal Programme (MINECO) RYC-2012-10651. The CNIO Proteomics Unit belongs to ProteoRed, PRB2-ISCIII, supported grant PT13/0001.
From the Human Genome to the Human Proteome†
Article first published online: 30 JUL 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
How to Cite
Muñoz, J. and Heck, A. J. R. (2014), From the Human Genome to the Human Proteome. Angew. Chem. Int. Ed.. doi: 10.1002/anie.201406545
- Article first published online: 30 JUL 2014
- Manuscript Received: 24 JUN 2014
- Netherlands Organization for Scientific Research (NWO)
- European Union
- Ramon y Cajal Programme (MINECO). Grant Number: RYC-2012-10651
- human genome;
- human proteome;
- mass spectrometry;
A herculean task: Determining the human proteome sets the ultimate challenge in cell biology as it is thought to consist of more than 1 000 000 proteoforms, in contrast to “only” 20 000 protein-coding genes. Two teams of researchers have now proved the translation of 18 000 proteins (and more than 27 000 isoforms) by mass spectrometry. They obtained important information on the extent of protein translation and alternative splicing.