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Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment

Authors

  • Min Soh,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea
    2. School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
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    • These authors contributed equally to this work.

  • Dr. Dong-Wan Kang,

    1. Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
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    • These authors contributed equally to this work.

  • Dr. Han-Gil Jeong,

    1. Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
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  • Dr. Dokyoon Kim,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea
    2. School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
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  • Dr. Do Yeon Kim,

    1. Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
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  • Dr. Wookjin Yang,

    1. Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
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  • Changyeong Song,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea
    2. School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
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  • Seungmin Baik,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea
    2. School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
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  • In-Young Choi,

    1. Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
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  • Seul-Ki Ki,

    1. Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
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  • Hyek Jin Kwon,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea
    2. School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
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  • Dr. Taeho Kim,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea
    2. School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
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  • Prof. Dr. Chi Kyung Kim,

    1. Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    2. Department of Neurology, Korea University Guro Hospital and Korea University College of Medicine, Seoul, Republic of Korea
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  • Prof. Dr. Seung-Hoon Lee,

    Corresponding author
    1. Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
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  • Prof. Dr. Taeghwan Hyeon

    Corresponding author
    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea
    2. School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
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Abstract

The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2− and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.

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Article Information

DOI

10.1002/anie.201704904

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© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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Keywords

  • ceria–zirconia nanoparticles;
  • inflammation;
  • reactive oxygen species;
  • sepsis;
  • therapeutic nanomedicine

Publication History

  • Version of record online:
  • Accepted manuscript online:
  • Manuscript Received:

Funded by

  • Korea Basic Science Institute. Grant Number: IBS-R006-D1
  • Ministry of Health and Welfare. Grant Number: HI14C0211
  • Ministry of Science, ICT and Future Planning. Grant Number: NRF-2015R1A2A2A01007770

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