Prof. Dr. Albrecht Mannschreck, Dipl.-Ing. Peter Roza, Prof. Dr. Hans Brockmann jr. and Dr. Thorsten Kemmer
Intermolecular interactions in solution, such as the formation of donor-acceptor complexes, can be readily studied by 1H-NMR spectroscopy by means of a trick in the case of chiral compounds. Reaction of the donor, e.g. (RS)-(1), with an optically active acceptor, e.g. (R)-(2), gives the two diastereomeric complexes [(R)-(1) + (R)-(2)] and [(S)-(1) + (R)-(2)], whose NMR spectra differ: a signal splitting is observed.