Dr. Paul Naab, dipl.-Chem. ETH René Lattmann, dipl.-Naturwiss. ETH Christof Angst and Prof. Dr. Albert Eschenmoser
A model substrate for studies in the hexahydroporphyrin series, i.e. the title compound (1) having C2v symmetry, has been prepared by a multistep de-novo synthesis from a cyanosubstituted thiolactam. Catalytic hydrogenation of (1) affords the highly O2-sensitive 2,3,7,8,15,24-hexahydro derivative; attempts to incorporate metal ions into this species lead to complexes of the 1,2,3,7,8,20-hexahydro isomer.