Total Synthesis of the Pseudoguaianolide (+)-Confertin (pages 61–62)
Prof. Dr. Gerhard Quinkert, Dr. Hans-Günther Schmalz, Dipl.-Chem. Egon -Walzer, Dr. Teresa Kowalczyk-Przewloka, Dr. Gerd Düner and Dr. Jan W. Bats
Version of Record online: 22 DEC 2003 | DOI: 10.1002/anie.198700611
The potential of the methyl derivative 1b as a chiral building block has been examined following the demonstrated usefulness of the compounds 1a and ent-1a.. 1b is equipped with the correct sense of chirality and the necessary functionality for stereoselective expansion of the three-membered ring and condensation of the seven-membered ring to give ( + )-confertin 2. The total synthesis of 2 is the first of an enantiomerically pure pseudoguaianolide.