Totally Enantioselective Inversion of Configuration of (S)-(+)-Carnitine Derivatives (pages 2076–2078)
Dipl.-Chem. Ida Bernabei, Dr. Roberto Castagnani, Prof. Dr. Francesco De Angelis, Paolo De Witt Scalfaro, Dr. Fabio Giannessi, Prof. Dr. Domenico Misiti, Dr. Sandra Muck, Dipl.-Chem. Nazareno Scafetta and Dr. Maria Ornella Tinti
Version of Record online: 22 DEC 2003 | DOI: 10.1002/anie.199420761
Tons of waste (S)-carnitinamide 1 are obtained in the industrial production of the (R) isomer 3, which is a biologically active pharmaceutical product. A method has now been developed to recycle 1 in a five-step reaction sequence with 80% overall yield via β-lactone 2.