Total Synthesis of (–)-Epothilone A (pages 2801–2803)
Dr. Aaron Balog, Dongfang Meng, Dr. Ted Kamenecka, Dr. Peter Bertinato, Dr. Dai-Shi Su, Dr. Erik J. Sorensen and Prof. Samuel J. Danishefsky
Article first published online: 22 DEC 2003 | DOI: 10.1002/anie.199628011
An audacious macroaldolization is the key step in the first total synthesis of the cytotoxic epothilone A, which starts with the units 1, 2, and 3. This condensation closes the ring to form the macrolide, whose structure was determined and published (also in Angewandte Chemie) as recently as July 1996.