Prof. Dr. Norbert Krause and Dipl.-Ing. Andreas Gerold
Organometallic reagents of unsurpassed versatility! Organocooper reagents are superbly suited for stereo- and regioselective syntheses, in particular those based on conjugate additions and SN2′ reactions. They have thus become indispensable in the synthesis of complex natural products and pharmaceuticals, chiral auxiliaries, and molecules with interesting structural features. One of the important new developments in this area is the extension of Michael additions to 1,6-, 1,8-, 1,10-, and 1,12-additions to acetylenic substrates.