Gemini Surfactants: New Synthetic Vectors for Gene Transfection (pages 1448–1457)
Anthony J. Kirby, Patrick Camilleri, Jan B. F. N. Engberts, Martin C. Feiters, Roeland J. M. Nolte, Olle Söderman, Mark Bergsma, Paul C. Bell, Matthew L. Fielden, Cristina L. García Rodríguez, Philippe Guédat, Andreas Kremer, Caroline McGregor, Christele Perrin, Gaël Ronsin and Marcel C. P. van Eijk
Version of Record online: 7 APR 2003 | DOI: 10.1002/anie.200201597
The powerful combination of the superior surfactant properties of gemini surfactants with the cationic character necessary for binding and compacting DNA has led to a new class of gene transfection agents (e.g. 1). The compounds are derived from natural metabolites and combine high transfection activity with low cell toxicity.