Synthesis of Versatile Chiral N,P Ligands Derived from Pyridine and Quinoline (pages 70–74)
William J. Drury III, Nicole Zimmermann, Martine Keenan, Masahiko Hayashi, Stefan Kaiser, Richard Goddard and Andreas Pfaltz
Article first published online: 17 DEC 2003 | DOI: 10.1002/anie.200352755
Potent transition-metal complexes for asymmetric catalysis are formed from readily accessible N,P ligands constructed from basic N-heteroaryl building blocks (see structure). Their simple assembly should not be misconstrued: they posses several handles by which to tune both steric and electronic parameters. The potential of these ligands is demonstrated by the high levels of enantioselection they induce in such divergent processes as asymmetric hydrogenation and the Heck reaction.