Dimeric Aminoglycosides as Antibiotics (pages 1562–1566)
Fabio Agnelli, Steven J. Sucheck, Kenneth A. Marby, David Rabuka, Su-Lan Yao, Pamela S. Sears, Fu-Sen Liang and Chi-Huey Wong
Version of Record online: 9 MAR 2004 | DOI: 10.1002/anie.200353225
Double duty: Dimeric aminoglycoside antibiotics were designed by linking neamine or nebramine cores with various tethers differing in length and composition. The resulting dimeric aminoglycosides displayed high affinity for the 16S A site of ribosomal RNA (a representation of the complex is shown here) and were effective against various aminoglycoside-resistant bacterial strains.