Total Synthesis of Natural Myriaporones (pages 1724–1727)
Marta Pérez, Carlos del Pozo, Fernando Reyes, Alberto Rodríguez, Andrés Francesch, Antonio M. Echavarren and Carmen Cuevas
Version of Record online: 17 MAR 2004 | DOI: 10.1002/anie.200353313
The relative and absolute configuration of the cytotoxic myriaporones (e.g. 4) was assigned by their total synthesis from aldehyde 1. Key steps included aldol reactions with chiral oxazolidinone 2 and with Weinreb amide 3. TBS=tert-butyldimethylsilyl, PMB=p-methoxybenzyl.