Identification of Potent Ras Signaling Inhibitors by Pathway-Selective Phenotype-Based Screening (pages 450–454)
Oliver Müller, Eleni Gourzoulidou, Mercedes Carpintero, Ioanna-Maria Karaguni, Anette Langerak, Christian Herrmann, Tarik Möröy, Ludger Klein-Hitpaß and Herbert Waldmann
Article first published online: 14 JAN 2004 | DOI: 10.1002/anie.200352587
Blocking the path to cancer: Application of efficient strategy for a phenotype-based screening of compound libraries to a library of sulindac-derived compounds (see scheme) yielded new inhibitors of the tumor-relevant Ras signal transduction pathway with high fidelity (as shown by microscopy). The results underline the advantage of using biologically prevalidated compound classes in chemical biology research.