Reactivity-Based One-Pot Synthesis of Oligomannoses: Defining Antigens Recognized by 2G12, a Broadly Neutralizing Anti-HIV-1 Antibody (pages 1000–1003)
Hing-Ken Lee, Christopher N. Scanlan, Cheng-Yuan Huang, Aileen Y. Chang, Daniel A. Calarese, Raymond A. Dwek, Pauline M. Rudd, Dennis R. Burton, Ian. A. Wilson and Chi-Huey Wong
Article first published online: 11 FEB 2004 | DOI: 10.1002/anie.200353105
An HIV-1 vaccine may eventually be developed from oligomannoses synthesized by a reactivity-based one-pot self-condensation strategy. The compounds were tested for their ability to inhibit the binding of gp120 to the broadly neutralizing HIV-1 antibody 2G12. New epitope mimics (see structure for example) were identified that inhibit this binding as well as, or better than the natural epitope Man9GlcNAc2 (Man=mannose, Glc=glucose).