The Design and Evaluation of Heparin-Binding Foldamers (pages 6685–6689)
Sungwook Choi, Dylan J. Clements, Vojislava Pophristic, Ivaylo Ivanov, Satyavani Vemparala, Joel S. Bennett, Michael L. Klein, Jeffrey D. Winkler and William F. DeGrado
Article first published online: 11 AUG 2005 | DOI: 10.1002/anie.200501279
Controlling blood loss: The synthesis of a series of arylamide oligomers 1, which interact with heparin is described. The heparin–small molecule interaction inhibits the heparin's ability to activate antithrombin. These arylamide oligomers are the first example of low-molecular-weight antagonists that inhibit the anticoagulant function of heparin.