A General and Efficient Method for the Formylation of Aryl and Heteroaryl Bromides (pages 154–158)
Stefan Klaus, Helfried Neumann, Alexander Zapf, Dirk Strübing, Sandra Hübner, Juan Almena, Thomas Riermeier, Peter Groß, Martin Sarich, Wolf-Rüdiger Krahnert, Kai Rossen and Matthias Beller
Article first published online: 22 NOV 2005 | DOI: 10.1002/anie.200502697
The key to the general and efficient palladium-catalyzed formylation of aryl and heteroaryl bromides is the use of the di-1-adamantyl-n-butylphosphane (cataCXium A) as ligand. Low pressure of the synthesis gas and appropriate choice of the base are also important for high yields (up to 99 %) of a broad range of (hetero)aromatic aldehydes at unprecedented low catalyst concentrations (see scheme; TMEDA= N,N,N′,N′-tetramethylethylenediamine).