Angewandte Chemie International Edition

Cover image for Vol. 45 Issue 33

August 18, 2006

Volume 45, Issue 33

Pages 5397–5559

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
    1. Cover Picture: Toward the Total Synthesis of Spirastrellolide A. Part 1: Strategic Considerations and Preparation of the Southern Domain / Toward the Total Synthesis of Spirastrellolide A. Part 2: Conquest of the Northern Hemisphere (Angew. Chem. Int. Ed. 33/2006) (page 5397)

      Alois Fürstner, Michaël D. B. Fenster, Bernhard Fasching, Cédrickx Godbout and Karin Radkowski

      Article first published online: 11 AUG 2006 | DOI: 10.1002/anie.200690112

      The antimitotic natural product spirastrellolide A is a complicated structure that shows impressive biological effects. Many key issues remain unresolved for this compound, for example its relative and absolute configurations and its biological mode of action. In two Communications on pages 5506 and 5510 ff., Fürstner and co-workers describe the synthesis of all four fragments of spirastrellolide A—initial strides in answering these questions. (Image of cell undergoing mitosis: Conley Rieder.)

  2. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
    1. Graphical Abstract: Angew. Chem. Int. Ed. 33/2006 (pages 5400–5409)

      Article first published online: 11 AUG 2006 | DOI: 10.1002/anie.200690113

  3. Obituary

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
  4. Book Reviews

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
  5. Highlights

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
    1. Soft Actuators Based on Liquid-Crystalline Elastomers (pages 5416–5418)

      Yanlei Yu and Tomiki Ikeda

      Article first published online: 3 AUG 2006 | DOI: 10.1002/anie.200601760

      Thumbnail image of graphical abstract

      Molecules that twitch: Liquid-crystalline elastomers (LCEs) show promise in applications as soft actuators, with advantages such as large deformations and high-speed, two- (contraction) or three-dimensional (bending) actions. Earlier systems were macroscopic (mm/cm) in size; however, a soft lithography technique called replica molding was recently used to create LCE pillars on the micrometer scale.

  6. Minireview

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
    1. Chemical Locomotion (pages 5420–5429)

      Walter F. Paxton, Shakuntala Sundararajan, Thomas E. Mallouk and Ayusman Sen

      Article first published online: 28 JUN 2006 | DOI: 10.1002/anie.200600060

      Thumbnail image of graphical abstract

      Doing the locomotion! As an alternative to using localized physical interactions and chemical reactions to propel small objects, catalysis can be used to translate the free chemical energy of the surroundings into asymmetric gradients, which result in directed mechanical motion. These approaches and some aspects of converting chemical energy into mechanical energy on the micrometer scale are discussed in the Minireview.

  7. Review

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
    1. CF3-Bearing Aromatic and Heterocyclic Building Blocks (pages 5432–5446)

      Manfred Schlosser

      Article first published online: 18 JUL 2006 | DOI: 10.1002/anie.200600449

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      Doesn't grow on trees: Trifluoromethyl-substituted substances are “unnatural” without exception. To prepare them, one has to choose among principal synthetic strategies: to replace other heteroatoms by fluorine, to transfer the CF3 entity as a whole from a small precursor to a preconstructed skeleton, or to start with a CF3-bearing core compound and to add the missing structural parts, in particular functionality (see scheme).

  8. Communications

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
    1. From a Bismuth Oxido Diketonate to a Giant Bismuth Oxido Cluster (pages 5448–5451)

      Evgeny V. Dikarev, Haitao Zhang and Bo Li

      Article first published online: 26 JUL 2006 | DOI: 10.1002/anie.200601675

      Thumbnail image of graphical abstract

      Aggregation in coordinating solvents: A giant oxido cluster [Bi38O45(hfac)24] (hfac=hexafluoroacetylacetonate), formed in solutions of bismuth oxido diketonate [Bi9O7(hfac)13], has been isolated and fully characterized. The [Bi38O45]24+ core (see picture: orange Bi, red O; central Bi6O9 unit is highlighted) is capped by 24 hfac ligands, has a size larger than 2 nm, and may serve as a model for investigating the chemistry of bismuth oxide nanoparticles.

    2. Prins Cyclizations in Au-Catalyzed Reactions of Enynes (pages 5452–5455)

      Eloísa Jiménez-Núñez, Christelle K. Claverie, Cristina Nieto-Oberhuber and Antonio M. Echavarren

      Article first published online: 19 JUL 2006 | DOI: 10.1002/anie.200601575

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      Going for gold: AuI-catalyzed cyclizations of functionalized enynes lead to the ready assembly of tricyclic carbon skeletons that are present in a number of naturally occurring compounds. An alkenyl gold intermediate is formed in the cyclization of the enynes and can be trapped in 5-exo-dig or 6-endo-dig Prins reactions to form an additional C[BOND]C bond. Z=C(CO2Me)2, NTs; R=H, Me, iPr.

    3. Cationic η12-Gold(I) Complexes of Simple Arenes (pages 5455–5459)

      Elena Herrero-Gómez, Cristina Nieto-Oberhuber, Salomé López, Jordi Benet-Buchholz and Antonio M. Echavarren

      Article first published online: 11 AUG 2006 | DOI: 10.1002/anie.200601688

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      In close contact: The first gold(I) complexes of simple arenes show a separation between the Au center and the mean aromatic plane of 2.20–2.24 Å, which is much shorter than the related silver(I)–arene bonds.

    4. An [FeII3O]4+ Core Wrapped by Two [FeIIL3] Units (pages 5459–5461)

      Ko Yoneda, Keiichi Adachi, Kyonosuke Nishio, Mikio Yamasaki, Akira Fuyuhiro, Motomi Katada, Sumio Kaizaki and Satoshi Kawata

      Article first published online: 7 AUG 2006 | DOI: 10.1002/anie.200602067

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      An [FeII3O]4+core in a candy wrapper: 3,5-Bis(pyridin-2-yl)pyrazolate (L) and iron(II) ions undergo homochiral self-assembly into a bis(triple-helical) cluster (see picture), in which a triangular [FeII3O]4+ core (Fe orange and yellow, O red) is surrounded by two [FeIIL3] units (Fe purple, L gray).

    5. Guest-Induced Instant and Reversible Crystal-to-Crystal Transformation of 1,4-Bis(ferrocenylethynyl)anthraquinone (pages 5461–5464)

      Mio Kondo, Masaki Murata, Hiroshi Nishihara, Eiji Nishibori, Shinobu Aoyagi, Masanori Yoshida, Yusuke Kinoshita and Makoto Sakata

      Article first published online: 19 JUL 2006 | DOI: 10.1002/anie.200600933

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      Both porous and nonporous structures are formed by crystals of donor–acceptor (D–A) compound 1,4-bis(ferrocenylethynyl)anthraquinone. The guest-incorporating porous and guest-free nonporous structures can interchange instantly and reversibly by desorption and adsorption of guest molecules, which cause alternation of D–A and D–A–A arrangements in the one-dimensional columnar structure (see picture).

    6. Supramolecular Control of Oligosaccharide–Protein Interactions: Switchable and Tunable Ligands for Concanavalin A Based on β-Cyclodextrin (pages 5465–5468)

      Nicolas Smiljanic, Vincent Moreau, Duplex Yockot, Juan M. Benito, José M. García Fernández and Florence Djedaïni-Pilard

      Article first published online: 20 JUL 2006 | DOI: 10.1002/anie.200601123

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      The ins and outs of binding: Supramolecular control of carbohydrate–protein interactions has been achieved through the design of β-cyclodextrin (βCD) based conjugates whose conformation is dependent on a reversible self-inclusion process. The accessibility of glycoligands to the lectin binding site is then regulated by allosteric inclusion of effector/antagonist-like molecules in the βCD cavity (see scheme).

    7. Switching On Cell Adhesion with Microelectrodes (pages 5469–5471)

      Chuan Zhao, Irene Witte and Gunther Wittstock

      Article first published online: 20 JUL 2006 | DOI: 10.1002/anie.200601151

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      Stick it! A microelectrochemical method was developed for in situ manipulation of the cell-adhesive property of an oligo(ethylene glycol)-terminated self-assembled monolayer substrate (OEG SAM) and subsequent cell adhesion and growth.

      Corrected by:

      Corrigendum: Switching On Cell Adhesion with Microelectrodes

      Vol. 45, Issue 46, 7660, Article first published online: 20 NOV 2006

    8. Microsphere-Based Real-Time Calcium Sensing (pages 5472–5474)

      Rosario M. Sánchez-Martín, Matt Cuttle, Stifun Mittoo and Mark Bradley

      Article first published online: 17 JUL 2006 | DOI: 10.1002/anie.200601242

      Thumbnail image of graphical abstract

      Sensing within the cell: Microspheres (2 μm) covalently loaded with calcium sensors can be delivered efficiently into living cells to analyze the intracellular changes in the concentration of Ca2+ ions in real time. The figure shows the real-time ratiometric fluorescent analysis (400/475 nm ratio) of the release of Ca2+ ions in cells loaded with the microspheres.

    9. Charge-Transfer Emission in Nonplanar Three-Coordinate Organoboron Compounds for Fluorescent Sensing of Fluoride (pages 5475–5478)

      Xiang Yang Liu, Dong Ren Bai and Suning Wang

      Article first published online: 19 JUL 2006 | DOI: 10.1002/anie.200601286

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      A real turn-on: Two nonplanar three-coordinate boron compounds were synthesized as fluorescent sensors for fluoride that utilize charge-transfer emission. The fluorescence of one of the sensors turns on (see picture) and the other turns off in the presence of fluoride.

    10. Multifunctional Lipid/Quantum Dot Hybrid Nanocontainers for Controlled Targeting of Live Cells (pages 5478–5483)

      Gopakumar Gopalakrishnan, Christophe Danelon, Paulina Izewska, Michael Prummer, Pierre-Yves Bolinger, Isabelle Geissbühler, Davide Demurtas, Jacques Dubochet and Horst Vogel

      Article first published online: 18 JUL 2006 | DOI: 10.1002/anie.200600545

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      Hydrophobic quantum dots can be incorporated into the bilayer membrane of lipid vesicles for selective delivery into either plasma membranes or the cytoplasm of living cells (see picture). The cell and lipid membranes can integrate any kind of hydrophobic nanoparticle whose size matches the membrane thickness, thus opening possibilities for their manipulation in nanobiotechnology applications.

    11. Interstrand Interactions between Side Chains in a Double-Helical Foldamer (pages 5483–5486)

      Debasish Haldar, Hua Jiang, Jean-Michel Léger and Ivan Huc

      Article first published online: 19 JUL 2006 | DOI: 10.1002/anie.200600698

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      Hairy molecules! The numerous benzyloxy side chains sticking out of a helically folded pyridine carboxamide oligomer bring about considerable stabilization to its double-helical conformation. The structure of the duplex was studied both in solution and in the solid state.

    12. [1,2,3]Triazolo[4,5-b]porphyrins: New Building Blocks for Porphyrinic Materials (pages 5487–5491)

      Paula S. S. Lacerda, Ana M. G. Silva, Augusto C. Tomé, Maria G. P. M. S. Neves, Artur M. S. Silva, José A. S. Cavaleiro and Antonio L. Llamas-Saiz

      Article first published online: 18 JUL 2006 | DOI: 10.1002/anie.200600747

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      An attractive target: Multiple porphyrin systems (see picture for example) are at the center of many synthetic efforts, and efficient strategies for preparing valuable building blocks for these polycycles are much sought after. Herein such a strategy for the synthesis of [1,2,3]triazolo[4,5-b]porphyrin building blocks is presented.

    13. Ion Exchange as a Way of Controlling the Chemical Compositions of Nano- and Microparticles Made from Infinite Coordination Polymers (pages 5492–5494)

      Moonhyun Oh and Chad A. Mirkin

      Article first published online: 21 JUL 2006 | DOI: 10.1002/anie.200601918

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      Ion balls: The composition of nano- and microparticles made from infinite coordination polymers can be chemically transformed through ion-exchange reactions without substantially changing the particle size and morphology. This approach is a straightforward and useful way of creating one precursor set of particles whose composition can be controllably transformed into that of a new set of compounds with different properties.

    14. Conjugated Polymers Complexed with Helical Porphyrin Oligomers Create Micron-Sized Ordered Structures (pages 5494–5499)

      Masayuki Takeuchi, Chiaki Fujikoshi, Yohei Kubo, Kenji Kaneko and Seiji Shinkai

      Article first published online: 18 JUL 2006 | DOI: 10.1002/anie.200601493

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      Straight curls: Conjugated polymers are aligned through the use of twining porphyrin oligomers (twimers), which act as helical “hosts” that twine around and are included within a single conjugated polymer. The resulting composites aggregate into relatively large 2D structures in the solid state and exhibit well-oriented periodic striping.

    15. Variable-Temperature Measurements of the Single-Molecule Conductance of Double-Stranded DNA (pages 5499–5502)

      Harm van Zalinge, David J. Schiffrin, Andrew D. Bates, Evgeni B. Starikov, Wolfgang Wenzel and Richard J. Nichols

      Article first published online: 7 AUG 2006 | DOI: 10.1002/anie.200601263

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      A sound result: Calculations have demonstrated a strong influence of acoustic modes on the conductance of double-stranded DNA (transmission spectrum of a duplex in its ideal B-DNA conformation is shown in red, that with deformations along DNA acoustic modes in green). The observed temperature independence of the conductivity at and above room temperature arises from a high overall population of such modes above the Debye temperature.

    16. A Priori Theoretical Prediction of Selectivity in Asymmetric Catalysis: Design of Chiral Catalysts by Using Quantum Molecular Interaction Fields (pages 5502–5505)

      James C. Ianni, Venkatachalam Annamalai, Puay-Wah Phuan, Manoranjan Panda and Marisa C. Kozlowski

      Article first published online: 11 AUG 2006 | DOI: 10.1002/anie.200600329

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      Excellent forecast: The selectivities for a set of chiral catalysts were predicted by methods derived from quantum mechanical molecular interaction fields that were applied to ground-state structures rather than transition-state structures. The predictions for the asymmetric addition of Et2Zn to PhCHO are in remarkable agreement with the experimental results (equation image=0.87).

    17. Toward the Total Synthesis of Spirastrellolide A. Part 1: Strategic Considerations and Preparation of the Southern Domain (pages 5506–5510)

      Alois Fürstner, Michaël D. B. Fenster, Bernhard Fasching, Cédrickx Godbout and Karin Radkowski

      Article first published online: 5 JUL 2006 | DOI: 10.1002/anie.200601654

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      North and South: The unique biological activity of the natural product spirastrellolide A renders it an attractive lead for anticancer agents. The southern hemisphere (C1–C25) and the northern hemisphere (including the chlorinated [5,6,6]-bis-spiroacetal entity and the lateral C42–C47 chain) are prepared by concise and efficient routes. Consequently, the entire carbon framework of this potent phosphatase inhibitor, which contains 21 chiral centers, is prepared in an optically active form, and an important step toward structure determination by total synthesis is achieved.

    18. Toward the Total Synthesis of Spirastrellolide A. Part 2: Conquest of the Northern Hemisphere (pages 5510–5515)

      Alois Fürstner, Michaël D. B. Fenster, Bernhard Fasching, Cédrickx Godbout and Karin Radkowski

      Article first published online: 11 AUG 2006 | DOI: 10.1002/anie.200601655

      Thumbnail image of graphical abstract

      North and South: The unique biological activity of the natural product spirastrellolide A renders it an attractive lead for anticancer agents. The southern hemisphere (C1–C25) and the northern hemisphere (including the chlorinated [5,6,6]-bis-spiroacetal entity and the lateral C42–C47 chain) are prepared by concise and efficient routes. Consequently, the entire carbon framework of this potent phosphatase inhibitor, which contains 21 chiral centers, is prepared in an optically active form, and an important step toward structure determination by total synthesis is achieved.

    19. Synthesis of Triphosphorous Bidentate Phosphine–Phosphoramidite Ligands: Application in the Highly Enantioselective Hydrogenation of ortho-Substituted Aryl Enamides (pages 5515–5518)

      Weicheng Zhang and Xumu Zhang

      Article first published online: 7 AUG 2006 | DOI: 10.1002/anie.200601501

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      New couple: A novel combination of phosphine and phosphoramidite groups is applied to the preparation of pseudo-C2-symmetric triphosphorous bidentate phosphine–phosphoramidite ligands 1. Unprecedented enantioselectivities toward ortho-substituted aryl enamides and a 1-naphthylenamide in Rh-catalyzed hydrogenation reactions are obtained.

    20. Bis(Dpa-ZnII) Appended Xanthone: Excitation Ratiometric Chemosensor for Phosphate Anions (pages 5518–5521)

      Akio Ojida, Hiroshi Nonaka, Yoshifumi Miyahara, Shun-ichi Tamaru, Kazuki Sada and Itaru Hamachi

      Article first published online: 18 JUL 2006 | DOI: 10.1002/anie.200601315

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      A xanthone-based chemosensor bears two 2,2′-dipicolylamine–zinc(II) sites and displays changes in the excitation spectrum at three wavelengths upon binding phosphates (see picture). These changes in the signals arise from the coordination rearrangement of the xanthone fluorophore around the zinc centers, which modulates the photophysical property of the chemosensor, thus enabling ratiometric fluorescent analysis.

    21. Water: The Ideal Hydrogen-Atom Source in Free-Radical Chemistry Mediated by TiIII and Other Single-Electron-Transfer Metals? (pages 5522–5526)

      Juan M. Cuerva, Araceli G. Campaña, José Justicia, Antonio Rosales, Juan L. Oller-López, Rafael Robles, Diego J. Cárdenas, Elena Buñuel and J. Enrique Oltra

      Article first published online: 19 JUL 2006 | DOI: 10.1002/anie.200600831

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      Hydrogen-atom transfer from water to free radicals can be mediated by aqua complexes of titanium(III) (see scheme). Asymmetric epoxidation in combination with [Cp2TiCl]/H2O-mediated reductive epoxide opening can be viewed as an alternative with complementary stereoselectivity to the hydroboration–epoxidation method for the enantioselective synthesis of anti-Markovnikov alcohols from alkenes.

      Corrected by:

      Corrigendum: Water: The Ideal Hydrogen-Atom Source in Free-Radical Chemistry Mediated by TiIII and Other Single-Electron-Transfer Metals?

      Vol. 46, Issue 12, 1941, Article first published online: 2 MAR 2007

    22. Combined Proline–Surfactant Organocatalyst for the Highly Diastereo- and Enantioselective Aqueous Direct Cross-Aldol Reaction of Aldehydes (pages 5527–5529)

      Yujiro Hayashi, Seiji Aratake, Tsubasa Okano, Junichi Takahashi, Tatsunobu Sumiya and Mitsuru Shoji

      Article first published online: 20 JUL 2006 | DOI: 10.1002/anie.200601156

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      Why not combine the two? The asymmetric direct aldol reaction of two different aldehydes was catalyzed by a combined proline–surfactant organic catalyst in the presence of water. A stable emulsion was formed in the reaction mixture, and the aldols were obtained with excellent diastereo- and enantioselectivities (see scheme).

    23. Protons at Ice Surfaces (pages 5529–5533)

      Chang-Woo Lee, Poong-Ryul Lee and Heon Kang

      Article first published online: 18 JUL 2006 | DOI: 10.1002/anie.200601317

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      Starry, starry ice: A study of proton transfer and H/D exchange in ice films shows that the proton mainly resides at their surface. It can move a short distance by a hopping relay mechanism (see picture) even when molecular motion is virtually frozen. This unique mobility and surface affinity suggest the possibility for proton-catalyzed reactions on cold ice surfaces, such as on interstellar dust particles.

    24. Ruthenium-Mediated Coupling/Cycloaddition of the Cyclopentadienyl Ligand in [{η5:σ-Me2C(C5H4)(C2B10H10)}Ru(NCCH3)2] with Alkynes (pages 5533–5536)

      Yi Sun, Hoi-Shan Chan, Haitao Zhao, Zhenyang Lin and Zuowei Xie

      Article first published online: 17 JUL 2006 | DOI: 10.1002/anie.200601650

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      Facile formation of tricycles: Ruthenium-mediated coupling/cycloaddition of a cyclopentadienyl ligand with aromatic alkynes offers a facile route to tricyclic compounds (see scheme). The sterically demanding carborane moiety plays a crucial role in regioselective dimerization of alkynes (to give head-to-tail coupling products) and prevents alkyne trimerization.

    25. Hierarchical Structures Built from a Molecular Zinc Phosphate Core (pages 5536–5540)

      Ramaswamy Murugavel, Subramaniam Kuppuswamy, Ramamoorthy Boomishankar and Alexander Steiner

      Article first published online: 18 JUL 2006 | DOI: 10.1002/anie.200601704

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      Playing with blocks: Zinc phosphate cubes with molecular structures that resemble the double-four-ring (D4R) secondary building unit of zeolites are prepared. When the appropriate ligands are chosen, the cubes assemble into 1D, 2D (see picture), or 3D supramolecular networks through hydrogen bonds that involve their surface functional groups.

    26. Synthesis of Enantiomerically Pure Bicyclo[4.2.0]octanes by Cu-Catalyzed [2+2] Photocycloaddition and Enantiotopos-Differentiating Ring Opening (pages 5541–5543)

      Ingbert Braun, Florian Rudroff, Marko D. Mihovilovic and Thorsten Bach

      Article first published online: 19 JUL 2006 | DOI: 10.1002/anie.200600946

      Thumbnail image of graphical abstract

      Fooling Mother Nature: When the bicyclo[4.2.0]octanes A are bridged as in precursors B (Z=CO), the otherwise impossible [2+2] photocycloaddition reaction of 1,7-dienes is possible with substrates such as C. A subsequent Baeyer–Villiger oxidation serves to desymmetrize substrates B and establishes a general approach to enantiomerically pure products A.

    27. Magnesium Bis(tetrahydridogallate(III)): Structure and Reaction with tert-Butyl Alcohol (pages 5544–5546)

      Michael Veith, Markus Burkhart and Volker Huch

      Article first published online: 21 JUL 2006 | DOI: 10.1002/anie.200600906

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      Unknown terrain: Mg(GaH4)2⋅4 OEt2 (see molecular structure; blue Ga, green Mg, red O, gray C, white H) can be regarded as a parent compound for the essentially unexplored group of alkaline-earth tetrahydridogallates. Reaction of Mg(GaH4)2⋅4 OEt2 with tert-butyl alcohol leads to {Mg(OtBu)[GaH2(OtBu)2]}2.

    28. Salt-Free Iridium-Catalyzed Asymmetric Allylic Aminations with N,N-Diacylamines and ortho-Nosylamide as Ammonia Equivalents (pages 5546–5549)

      Robert Weihofen, Olena Tverskoy and Günter Helmchen

      Article first published online: 20 JUL 2006 | DOI: 10.1002/anie.200601472

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      New variants of the iridium-catalyzed allylic substitution allow N-protected and non-protected chiral allylamines to be prepared with high enantio- and regioselectivity. The allylamines are used as nucleophiles in highly diastereoselective, catalyst-controlled allylic aminations. The products are transformed into N-non-protected 2,5-disubstituted 3,4-dehydropyrrolidines by ring-closing metathesis (RCM; see scheme).

    29. A Homogenous Assay for Micro RNA Maturation (pages 5550–5552)

      Brian P. Davies and Christoph Arenz

      Article first published online: 21 JUL 2006 | DOI: 10.1002/anie.200601332

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      Maturation process: Micro RNAs represent a recently (re-)discovered group of regulators of gene expression. Ligands of the inactive precursor RNAs (pre-miRNAs) inhibit the formation of the respective miRNAs. Such ligands could potentially be used as tools in biomedicine. A doubly labeled RNA beacon allows simple screening of potential pre-miRNA binders.

  9. Preview

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Obituary
    5. Book Reviews
    6. Highlights
    7. Minireview
    8. Review
    9. Communications
    10. Preview
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      Preview: Angew. Chem. Int. Ed. 33/2006 (page 5559)

      Article first published online: 11 AUG 2006 | DOI: 10.1002/anie.200690114

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