Total Synthesis of IKD-8344 (pages 7072–7075)
Woo Han Kim, Sung Kil Hong, Sang Min Lim, Min-Ae Ju, Soon Kyu Jung, Yong Wook Kim, Jae Hoon Jung, Min Sang Kwon and Eun Lee
Article first published online: 2 OCT 2006 | DOI: 10.1002/anie.200602860
Complete construction: The total synthesis of IKD-8344, a novel 28-membered ring macrodiolide antibiotic (see structure), was accomplished by employing Williamson ether synthesis, β-alkoxymethacrylate radical cyclization, and Yamaguchi lactonization reactions. This synthesis is another example of the application of β-alkoxymethacrylate radical cyclization reactions for the stereoselective construction of complex oxacyclic natural products.