Oxetanes as Promising Modules in Drug Discovery (pages 7736–7739)
Georg Wuitschik, Mark Rogers-Evans, Klaus Müller, Holger Fischer, Björn Wagner, Franz Schuler, Liudmila Polonchuk and Erick M. Carreira
Article first published online: 2 OCT 2006 | DOI: 10.1002/anie.200602343
Ring the changes: Introduction of an oxetane ring results in remarkably improved physico- and biochemical properties of the underlying scaffold. The oxetane ring confers enhanced solubility, reduces the metabolic degredation, lipophilicity, and amphiphilicity, and modulates the basicity of a nearby amine group.