Total Synthesis of (−)-Amphidinolide E (pages 8019–8021)
Chan Hyuk Kim, Hyo Jung An, Won Kyo Shin, Wei Yu, Sang Kook Woo, Soon Kyu Jung and Eun Lee
Article first published online: 9 NOV 2006 | DOI: 10.1002/anie.200603363
The unique structural features of the cytotoxic marine macrolide (−)-amphidinolide E make it an intriguing synthetic target. Its total synthesis has now been completed by employing a radical cyclization of a β-alkoxy acrylate to form the oxolane ring, a Kocienski–Julia olefination to create the E CC bond, and a lactonization reaction to close the macrocyclic ring.