Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate (pages 1810–1813)
Giovanni Maga, Marco Radi, Samantha Zanoli, Fabrizio Manetti, Reynel Cancio, Ulrich Hübscher, Silvio Spadari, Chiara Falciani, Montserrat Terrazas, Jaume Vilarrasa and Maurizio Botta
Version of Record online: 2 FEB 2007 | DOI: 10.1002/anie.200604165
How odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.