Structure and Total Synthesis of Lysobactin (Katanosin B) (pages 2039–2042)
Franz von Nussbaum, Sonja Anlauf, Jordi Benet-Buchholz, Dieter Häbich, Johannes Köbberling, László Musza, Joachim Telser, Helga Rübsamen-Waigmann and Nina A. Brunner
Article first published online: 9 JAN 2007 | DOI: 10.1002/anie.200604232
Tackle-resistant bacteria: Determination of the 3D structure of the antibiotic lysobactin has led to its total synthesis and resulted in a high-yielding macrolactamization step. The minimal use of protecting groups allowed preorganization of the side chains to steer the cyclization. Thus, a new chemical route has been developed in the search for innovative antibiotic lead structures.