Beryllium Displacement of H+ from Strong Hydrogen Bonds (pages 2669–2671)
T. Mark McCleskey, Deborah S. Ehler, Timothy S. Keizer, Dilip N. Asthagiri, Lawrence R. Pratt, Ryszard Michalczyk and Brian L. Scott
Version of Record online: 9 MAR 2007 | DOI: 10.1002/anie.200604623
It's bound to Be: The binding of beryllium to the iron transport protein transferrin proceeds by displacement of H+ from strong hydrogen bonds in the protein (see picture). This new view of beryllium binding, in which beryllium as a “tetrahedral proton” is thermodynamically preferred, provides insight into the transport mechanism of beryllium in chronic beryllium disease.