Angewandte Chemie International Edition

Cover image for Vol. 46 Issue 23

June 4, 2007

Volume 46, Issue 23

Pages 4193–4403

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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    1. Cover Picture: 3-Boryl-2,2′-bithiophene as a Versatile Core Skeleton for Full-Color Highly Emissive Organic Solids (Angew. Chem. Int. Ed. 23/2007) (page 4193)

      Atsushi Wakamiya, Kenji Mori and Shigehiro Yamaguchi

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200790102

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      Full-color highly emissive organic solids with fluorescence maxima ranging over a wide visible region (blue to deep red) can be produced by using 3-boryl-2,2-bithiophene as a core skeleton. In their Communication on page 4273 ff., S. Yamaguchi and co-workers describe the molecular design of emissive organic materials in which intramolecular charge transfer from the π-conjugated moiety to the boron moiety in the twisted framework plays a crucial role for attaining intense solid-state emissions with large Stokes shifts.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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    1. Inside Cover: Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D (Angew. Chem. Int. Ed. 23/2007) (page 4194)

      Regina M. Kanada, Daisuke Itoh, Mitsuo Nagai, Jun Niijima, Naoki Asai, Yoshiharu Mizui, Shinya Abe and Yoshihiko Kotake

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200790103

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      Pladienolides, 12-membered macrolides isolated from Streptomyces platensis Mer-11107, show prominent in vitro and in vivo antitumor activities based on a unique mode of action. Y. Kotake and co-workers describe in their Communication on page 4350 ff. the first total synthesis of this class of natural product, by an efficient coupling between macrolide and side-chain fragments, which confirmed the absolute structure and provided a practical method to prepare analogues.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
  5. Book Review

    1. Top of page
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    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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  6. Highlights

    1. Top of page
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    4. Graphical Abstract
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    6. Book Review
    7. Highlights
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    1. Approaching the Megadalton: NMR Spectroscopy of Protein Complexes (pages 4214–4216)

      Burkhard Luy

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200701093

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      Bigger and bigger: A decade ago the size limit for biomolecular NMR spectroscopy was thought to be on the order of 30 kDa. Now quantitative NMR-relaxation studies have been reported for a 670-kDa complex (see structure; red: Me groups with slow dynamics, yellow: Me groups at highly flexible N termini). The key developments that led to the remarkable work are presented.

    2. Relative Energy Computations with Approximate Density Functional Theory—A Caveat! (pages 4217–4219)

      Peter R. Schreiner

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200700386

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      Not so simple: Common and broadly used density functional theory (DFT) implementations do not properly account for medium-range electron correlation. The resultant errors in energy calculations, for example, for simple hydrocarbon isomers, can be large and increase with increasingly larger structures.

  7. Review

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    8. Review
    9. Communications
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    1. Recent Advances in Asymmetric Phase-Transfer Catalysis (pages 4222–4266)

      Takashi Ooi and Keiji Maruoka

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200601737

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      Chiral ion pair lends a hand: Asymmetric phase-transfer catalysis, as represented by chiral quaternary onium salts, has become an increasingly important method for the synthesis of optically active organic molecules. The multiple ion-exchange process catalytically generates a chiral ion pair, whose chiral onium cation creates an effective asymmetric environment around the nucleophilic anion and enables stereoselective bond formation (see scheme).

  8. Communications

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    6. Book Review
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    1. Amplification and Transcription of the Dynamic Supramolecular Chirality of the Guanine Quadruplex (pages 4268–4272)

      Carole Arnal-Hérault, Andreea Banu, Mihail Barboiu, Mathieu Michau and Arie van der Lee

      Article first published online: 10 MAY 2007 | DOI: 10.1002/anie.200700787

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      Transcribing twists: A new way to transcribe the supramolecular chirality of a dynamic G-quadruplex supramolecular architecture (G: guanine) is reported, thereby creating hybrid twisted nanorods or inorganic microsprings (see image). The first picture of a dynamic G-quadruplex transcribed at the nanometric level is reported.

    2. 3-Boryl-2,2′-bithiophene as a Versatile Core Skeleton for Full-Color Highly Emissive Organic Solids (pages 4273–4276)

      Atsushi Wakamiya, Kenji Mori and Shigehiro Yamaguchi

      Article first published online: 22 MAR 2007 | DOI: 10.1002/anie.200604935

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      Seeing the light: Tuning the electron-donating ability of the π-conjugated framework of bithiophene has resulted in intense solid-state emissions with maxima ranging over a wide visible region (see picture). Even a deep-red fluorescence with a large Stokes shift close to 200 nm, arising from the intramolecular charge-transfer (CT) transition from the twisted bithiophene π framework to the boron center, can be obtained.

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      δ Aromaticity in [Ta3O3] (pages 4277–4280)

      Hua-Jin Zhai, Boris B. Averkiev, Dmitry Yu. Zubarev, Lai-Sheng Wang and Alexander I. Boldyrev

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200700442

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      Low-lying electronic transitions are observed in the photoelectron spectra of [Ta3O3], and ab initio calculations show that the cluster has a planar D3h triangular structure. Totally delocalized, multicenter metal–metal bonding renders δ aromaticity for [Ta3O3] (see picture). This is the first δ-aromatic molecule to be confirmed both experimentally and theoretically.

    4. Inducing and Sensing Protein–Protein Interactions in Living Cells by Selective Cross-linking (pages 4281–4284)

      Guillaume Lemercier, Susanne Gendreizig, Maik Kindermann and Kai Johnsson

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200700408

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      Cells technique: Small molecules have been synthesized that enable the covalent and irreversible dimerization of fusion proteins of O6-alkylguanine-DNA alkyltransferase (AGT or SNAP-Tag) in vitro and in living cells. The cross-linking efficiency of AGT fusion proteins provides a measure to characterize the proximity and interactions of protein pairs in living cells (see scheme).

    5. A Supramolecular-Hydrogel-Encapsulated Hemin as an Artificial Enzyme to Mimic Peroxidase (pages 4285–4289)

      Qigang Wang, Zhimou Yang, Xieqiu Zhang, Xudong Xiao, Chi K. Chang and Bing Xu

      Article first published online: 19 APR 2007 | DOI: 10.1002/anie.200700404

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      Faking it: The use of a supramolecular hydrogel as the structural component of artificial enzymes provides a new and useful approach to the development of biomimetic catalysts. In toluene, hemin chloride encapsulated in such a hydrogel achieves about 60 % nascent catalytic activity of horseradish peroxidase. Additionally, the activity of hemin in the hydrogel is 387.1 times greater than that of free hemin.

    6. Photochemical Activation of Protein Expression in Bacterial Cells (pages 4290–4292)

      Douglas D. Young and Alexander Deiters

      Article first published online: 25 APR 2007 | DOI: 10.1002/anie.200700057

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      Turning genes on with light: Photochemical control of gene expression is a versatile tool for the elucidation of biological processes and the programming of new biological functions. Activation of protein expression in prokaryotic cells through light irradiation is achieved through a photocaged small molecule. Spatiotemporal regulation of the lac operon was obtained through the application of a photocaged isopropyl-β-D-thiogalactopyranoside derivative.

    7. Selective Adsorption and Separation of Xylene Isomers and Ethylbenzene with the Microporous Vanadium(IV) Terephthalate MIL-47 (pages 4293–4297)

      Luc Alaerts, Christine E. A. Kirschhock, Michael Maes, Monique A. van der Veen, Vincent Finsy, Anouschka Depla, Johan A. Martens, Gino V. Baron, Pierre A. Jacobs, Joeri F. M. Denayer and Dirk E. De Vos

      Article first published online: 4 MAY 2007 | DOI: 10.1002/anie.200700056

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      A breakthrough result: The microporous metal–organic framework MIL-47 is an excellent adsorbent for the separation of C8 alkylaromatic compounds, such as ethylbenzene, meta-xylene, and para-xylene. The potential of MIL-47, with its high uptake capacity and its hydrophobic nature, for real separations of the C8 alkylaromatic compounds was demonstrated by breakthrough and chromatographic experiments (see picture).

    8. Metal Oxide “Nanosponges” as Chemical Sensors: Highly Sensitive Detection of Hydrogen with Nanosponge Titania (pages 4298–4301)

      Abu Samah Zuruzi, Noel C. MacDonald, Martin Moskovits and Andrei Kolmakov

      Article first published online: 25 APR 2007 | DOI: 10.1002/anie.200700006

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      Sensitive sponges: Nanosponge titania (NST), integrated into a prototype device, has been used for ultrasensitive detection of hydrogen. NST has potential applications in multiplex sensing systems such as electronic noses and tongues, and three-dimensionally interconnected nanostructured metal oxides hold great promise as platforms for ultrasensitive sensors. The picture shows an SEM image of NST formed from 500-nm-thick Ti film.

    9. [(dpp-bian)Zn[BOND]Zn(dpp-bian)]: A Zinc–Zinc-Bonded Compound Supported by Radical-Anionic Ligands (pages 4302–4305)

      Igor L. Fedushkin, Alexandra A. Skatova, Sergey Y. Ketkov, Olga V. Eremenko, Alexander V. Piskunov and Georgy K. Fukin

      Article first published online: 4 MAY 2007 | DOI: 10.1002/anie.200605251

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      Radical help: The use of a spin-labeled ligand allows a zinc–zinc-bonded compound supported by radical-anionic ligands to be prepared (see scheme). The radical anion enabled the presence of the Zn[BOND]Zn bond in solution to be confirmed by ESR spectroscopy. DFT calculations confirm the biradical nature of the compound and indicate that the Zn[BOND]Zn bond is formed mainly by the metal s orbitals.

    10. Highly Stable Pyrimidine-Motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue (pages 4306–4309)

      S. M. Abdur Rahman, Sayori Seki, Satoshi Obika, Sunao Haitani, Kazuyuki Miyashita and Takeshi Imanishi

      Article first published online: 27 APR 2007 | DOI: 10.1002/anie.200604857

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      Good things come in threes: A novel bridged nucleic acid in which the furanose conformation was locked in the N form by a six-membered bridged moiety containing an N[BOND]O bond (see picture) has been developed. Triplex-forming oligonucleotides composed of this residue formed highly stable triplexes at physiological pH values.

    11. In Situ Time-Resolved Dynamic Surface Events on the Pt/C Cathode in a Fuel Cell under Operando Conditions (pages 4310–4315)

      Mizuki Tada, Shigeaki Murata, Takahiko Asakoka, Kazutaka Hiroshima, Kazu Okumura, Hajime Tanida, Tomoya Uruga, Haruyuki Nakanishi, Shin-ichi Matsumoto, Yasuhiro Inada, Masaharu Nomura and Yasuhiro Iwasawa

      Article first published online: 4 MAY 2007 | DOI: 10.1002/anie.200604732

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      On the Pt/C cathode in a fuel cell, dynamic surface events were investigated by novel X-ray absorption techniques (see Fourier transform for the oxidation process, 0.4[RIGHTWARDS ARROW]1.0 V). Evidence for Pt dissolution at the cathode was found, and the reaction kinetics of the electron-transfer processes, as well as redox structural changes and a significant time lag between the events, were observed for the first time under operando conditions.

    12. A Pocket-Sized Convective PCR Thermocycler (pages 4316–4319)

      Nitin Agrawal, Yassin A. Hassan and Victor M. Ugaz

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200700306

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      Is that a PCR in your pocket? An innovative thermocycling system is presented that harnesses natural convection to perform rapid multiplex and long-target DNA amplification by the polymerase chain reaction (PCR). The design is inherently simple and consumes minimal electrical power, enabling a pocket-sized battery-powered device to be constructed at a cost of approximately US$10.

    13. DNA Binding and Catalytic Properties of Positively Charged Corroles (pages 4320–4324)

      Zoya Gershman, Israel Goldberg and Zeev Gross

      Article first published online: 4 MAY 2007 | DOI: 10.1002/anie.200700757

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      DNA likes corroles and peroxynitrite doesn't: The water-soluble manganese corrole (crystal structure shown) is a much better catalyst than the analogous porphyrin for decomposition of peroxynitrite (HOONO). The interactions of the two complexes with DNA are also significantly different. These findings suggest that positively charged corroles may be useful for therapeutic approaches.

    14. Polymorphic Superelasticity in Semicrystalline Polymers (pages 4325–4328)

      Finizia Auriemma, Claudio De Rosa, Simona Esposito and Geoffrey R. Mitchell

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200605021

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      Under stress: A high level of crystallinity in polymers does not impair ductility and elastic performance if a stress-induced martensitic crystal–crystal phase transition takes place (see picture; c: unit cell axis, h: helical form, t: trans-planar form). This type of elasticity is not merely entropic but also partly enthalpic, and therefore similar to the superelasticity of shape-memory alloys.

    15. A Magnetic-Nanoparticle-Supported 4-N,N-Dialkylaminopyridine Catalyst: Excellent Reactivity Combined with Facile Catalyst Recovery and Recyclability (pages 4329–4332)

      Ciarán Ó Dálaigh, Serena A. Corr, Yurii Gun'ko and Stephen J. Connon

      Article first published online: 2 MAY 2007 | DOI: 10.1002/anie.200605216

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      Quick recovery: The first magnetic-nanoparticle-supported organocatalyst is prepared. The heterogeneous catalyst promotes a range of nucleophilic reactions and can be recovered by exposure to an external magnet (see picture). Furthermore, it can be recycled over 30 times without loss of activity.

    16. Selective Growth of a Stable Drug Polymorph by Suppressing the Nucleation of Corresponding Metastable Polymorphs (pages 4333–4336)

      Jason R. Cox, Lori A. Ferris and Venkat R. Thalladi

      Article first published online: 2 MAY 2007 | DOI: 10.1002/anie.200605257

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      To stick or not to stick? Metastable (α) and stable (γ) polymorphs of indomethacin crystallize concomitantly from ethanol solutions. Crystallization in glass vials functionalized with perfluoroalkyl-terminated silane monolayers, however, leads to the exclusive growth of the stable polymorph. These monolayers create surfaces that inhibit the heterogeneous nucleation of α polymorph and thereby promote the growth of γ polymorph.

    17. Hexasilylated Total Carbomer of Benzene (pages 4337–4341)

      Chunhai Zou, Carine Duhayon, Valérie Maraval and Remi Chauvin

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200605262

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      A close cousin of benzene: The cobalt-assisted reductive aromatization of a hexaalkynyl [6]pericyclyne afforded a fully expanded carbobenzene derivative (see scheme) as the first carbomer without stabilizing aromatic substituents. The triethylsilyl groups ensured high solubility and allowed full spectroscopic characterization of the aromatic macrocycle.

    18. Superparamagnetic Magnetite Colloidal Nanocrystal Clusters (pages 4342–4345)

      Jianping Ge, Yongxing Hu, Maurizio Biasini, Ward P. Beyermann and Yadong Yin

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200700197

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      High-temperature hydrolysis of FeCl3 in the presence of a surfactant gives monodisperse superparamagnetic colloidal nanocrystal clusters (CNCs) of magnetite with tunable sizes (30–180 nm; see scheme). The combination of superparamagnetism, high magnetization, and high water dispersibility makes these CNCs ideal candidates for applications such as drug delivery and bioseparation.

    19. Quantum Dot/Bioluminescence Resonance Energy Transfer Based Highly Sensitive Detection of Proteases (pages 4346–4349)

      Hequan Yao, Yan Zhang, Fei Xiao, Zuyong Xia and Jianghong Rao

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200700280

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      Sensing by BRET: Quantum dot (QD) nanosensors can detect the activity of matrix metalloproteinases by measuring the bioluminescence resonance energy transfer (BRET) efficiency between the QDs and a bioluminescent fusion protein (see scheme; Luc8=Renilla luciferase; His×6=six-histidine tag).

    20. Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D (pages 4350–4355)

      Regina M. Kanada, Daisuke Itoh, Mitsuo Nagai, Jun Niijima, Naoki Asai, Yoshiharu Mizui, Shinya Abe and Yoshihiko Kotake

      Article first published online: 17 APR 2007 | DOI: 10.1002/anie.200604997

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      Getting cross: The total syntheses of two pladienolides (see picture), which have prominent antitumor activity based on a unique mechanism of action, have been accomplished, and their absolute configurations were verified. The 12-membered aliphatic macrolide structure was formed by ring-closing metathesis, and the side-chain moiety was coupled to the macrolide by Julia–Kocienski olefination or cross-metathesis.

      Corrected by:

      Corrigendum: Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D

      Vol. 46, Issue 46, 8734, Article first published online: 16 NOV 2007

    21. Amino Acid Phosphoramidate Nucleotides as Alternative Substrates for HIV-1 Reverse Transcriptase (pages 4356–4358)

      Olga Adelfinskaya and Piet Herdewijn

      Article first published online: 19 APR 2007 | DOI: 10.1002/anie.200605016

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      Pick and choose: Amino acid phosphoramidites, in particular Asp-dAMP (dAMP=2′-deoxyadenosine-5′-monophosphate) and His-dAMP, act in a template-dependent DNA synthesis assay as alternative substrates for reverse transcriptase. L-Aspartic acid can function as a leaving group during DNA synthesis and can be considered as a pyrophosphate mimetic in this reaction.

    22. Total Synthesis of (−)-Ulapualide A: The Danger of Overdependence on NMR Spectroscopy in Assignment of Stereochemistry (pages 4359–4363)

      Gerald Pattenden, Neil J. Ashweek, Charles A. G. Baker-Glenn, Gary M. Walker and James G. K. Yee

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200700459

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      Lessons learnt: The asymmetric total synthesis of the macrolide (−)-ulapualide A has been accomplished. Interestingly, the 1H NMR spectrum and chiroptical data of the macrolide and of a previously synthesized diastereoisomer with opposite stereocenters at C3, C28, C29, C30, and C32 were superimposable, which highlights the care that must be taken in the assignment of configurations to complex structures based on NMR spectroscopy.

    23. Iron-Catalyzed Alkylations of Aromatic Grignard Reagents (pages 4364–4366)

      Gérard Cahiez, Vanessa Habiak, Christophe Duplais and Alban Moyeux

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200700742

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      Any old iron: Two efficient iron-catalyzed cross-coupling reactions between aryl Grignard reagents and alkyl bromides were developed that are suitable for large-scale applications. The first procedure uses iron acetylacetonate and involves a cooperative effect between the two ligands N,N,N′,N′-tetramethylethylenediamine (TMEDA) and hexamethylenetetraamine (HMTA), while the second procedure uses [(FeCl3)2(tmeda)3] as catalyst.

    24. Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes (pages 4367–4369)

      Xing Dai, Takashi Nakai, Jan A. C. Romero and Gregory C. Fu

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200700697

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      A-mine of possibilities: An effective method for the conversion of achiral ketenes into enantioenriched protected amines was developed by tuning the structure and reactivity of a catalyst on the basis of a mechanistic hypothesis. The method involved the catalytic asymmetric addition of hydrazoic acid to ketenes, followed by a Curtius rearrangement (see scheme).

    25. Integration of a Self-Assembling Protein Scaffold with Water-Soluble Single-Walled Carbon Nanotubes (pages 4370–4373)

      Patrick G. Holder and Matthew B. Francis

      Article first published online: 25 APR 2007 | DOI: 10.1002/anie.200700333

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      Plastic tubing: The parallel alignment of single-walled carbon nanotubes (NTs) with a self-assembling biomolecular scaffold, the tobacco mosaic virus (TMV), is presented. A multifunctional polymeric surfactant brings together these two disparate components: The NTs are solubilized by a layer of poly(ethylene glycol) attached through a pyrene anchor, and the pendant alkoxyamine groups of the surfactant allow mild bioconjugation with ketone-labeled proteins.

    26. Dinuclear Ruthenium(II) Triple-Stranded Helicates: Luminescent Supramolecular Cylinders That Bind and Coil DNA and Exhibit Activity against Cancer Cell Lines (pages 4374–4378)

      Gabriel I. Pascu, Anna C. G. Hotze, Carlos Sanchez-Cano, Benson M. Kariuki and Michael J. Hannon

      Article first published online: 4 MAY 2007 | DOI: 10.1002/anie.200700656

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      A fluorescent supramolecular cylinder binds noncovalently to DNA and shows anticancer activity in cell lines.

    27. Highly Selective Thiiranation of 1,2-Allenyl Sulfones with Br2 and Na2S2O3: Mechanism and Asymmetric Synthesis of Alkylidenethiiranes (pages 4379–4381)

      Chao Zhou, Chunling Fu and Shengming Ma

      Article first published online: 2 MAY 2007 | DOI: 10.1002/anie.200700619

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      Axial-to-central chirality transfer is highly efficient in a regioselective synthesis of (1-sulfonyl)alkylidenethiiranes from 1,2-allenyl sulfones (see scheme). A cyclic intermediate formed upon the electrophilic addition of bromine to the allene was isolated and characterized. A mechanism is proposed on the basis of this intermediate and the observed stereoselectivity.

    28. Polyamide Struts for DNA Architectures (pages 4382–4384)

      Thorsten L. Schmidt, Chayan K. Nandi, Goran Rasched, Partha P. Parui, Bernd Brutschy, Michael Famulok and Alexander Heckel

      Article first published online: 25 APR 2007 | DOI: 10.1002/anie.200700469

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      Copy and paste: A DNA strut consisting of two Dervan polyamides is constructed with two sides that can sequence-selectively bind double-stranded DNA. This strut can be used as sequence-selective glue for DNA architectures and can easily combine DNA objects that are 100 times its mass.

    29. equation image[Eu(Tzpy)2]: A Homoleptic Framework Containing {EuIIN12} Icosahedra (pages 4385–4387)

      Klaus Müller-Buschbaum, Yassin Mokaddem, Falko M. Schappacher and Rainer Pöttgen

      Article first published online: 4 MAY 2007 | DOI: 10.1002/anie.200603682

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      Eu assembly: The reaction of europium with 1H-1,2,3-triazolo[4,5-b]pyridine under solvothermal conditions in pyridine gives equation image[Eu(Tzpy)2]. This novel homoleptic framework contains EuII centers that are icosahedrally coordinated by the 12 nitrogen atoms of six chelating ligands (see picture; Eu bronze, C blue, N green).

    30. New Crosslinkable Hole Conductors for Blue-Phosphorescent Organic Light-Emitting Diodes (pages 4388–4392)

      Philipp Zacharias, Malte C. Gather, Markus Rojahn, Oskar Nuyken and Klaus Meerholz

      Article first published online: 4 MAY 2007 | DOI: 10.1002/anie.200605055

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      Shedding a blue light: A series of oxetane-functionalized crosslinkable triphenylamine dimers (XTPDs) is investigated as the hole-transport layers in blue-phosphorescent polymer light-emitting diodes (see scheme). These devices have improved performance characteristics, and their luminous efficiencies depend on the HOMO energies of the XTPDs.

    31. Supramolecular Structure of 5-nm Spherical Micelles with D3 Symmetry Assembled from Amphiphilic [3:3]-Hexakis Adducts of C60 (pages 4393–4396)

      Boris Schade, Kai Ludwig, Christoph Böttcher, Uwe Hartnagel and Andreas Hirsch

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200604784

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      Six molecules of an amphiphilic fullerene derivative make up the smallest persistent micelle detected so far (see picture, the six amphiphilic molecules are shown in different colors). These micelles can be used to systematically study the factors that determine the structural persistence of micelles and may lead to the design of tailor-made supramolecular containers.

    32. C2-Symmetric Metacyclophanes: A Possible Alternative to o,o′-Bridged Binaphthyls (pages 4397–4399)

      Gebhard Haberhauer

      Article first published online: 30 APR 2007 | DOI: 10.1002/anie.200605098

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      The trick with the chiral clamp: In metacyclophanes such as (P)-2 it is possible to stabilize one chiral conformation by means of a chiral clamp so effectively that at room temperature only this conformation is present. This conformation resembles that of o,o′-bridged binaphthyls (for example (P)-1). New binaphthyl alternatives are thus made accessible.

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    1. Top of page
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    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
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      Preview: Angew. Chem. Int. Ed. 24/2007 (page 4403)

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200790106

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