Angewandte Chemie International Edition

Cover image for Vol. 46 Issue 26

June 25, 2007

Volume 46, Issue 26

Pages 4799–5031

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
    1. Cover Picture: 10a-Aza-10b-borapyrenes: Heterocyclic Analogues of Pyrene with Internalized BN Moieties (Angew. Chem. Int. Ed. 26/2007) (page 4799)

      Michael J. D. Bosdet, Warren E. Piers, Ted S. Sorensen and Masood Parvez

      Article first published online: 15 JUN 2007 | DOI: 10.1002/anie.200790117

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      A new take on a classic aromatic molecule is offered by the conceptual “excision” of an internal C[BOND]C unit and the “insertion” of a B[BOND]N moiety, as shown in the cover picture (“cut and paste”). This introduction of a B[BOND]N dipole into the internal positions of pyrene, as described in the Communication by W. E. Piers and co-workers on page 4940 ff., was accomplished by using PtCl2-catalyzed cyclization of acetylide-substituted pyridine adducts of borabenzene to give a novel fluorescent heterocyclic species.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
    1. Inside Cover: Gas Hosting in Enantiopure Self-Assembled Oximes (Angew. Chem. Int. Ed. 26/2007) (page 4800)

      Alessandro Scarso, Leonardo Pellizzaro, Ottorino De Lucchi, Anthony Linden and Fabrizio Fabris

      Article first published online: 15 JUN 2007 | DOI: 10.1002/anie.200790118

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      In contrast to the macroscopic world where a vacuum keeps two hemispheres together, in the nanoscopic world, a vacuum cannot exist within closed surfaces. A. Scarso, F. Fabris, and co-workers demonstrate in their Communication on page 4972 ff. that a suitably tailored chiral molecule with pendant oxime moieties may dimerize to form a supramolecular cooperatively hydrogen-bonded capsule containing atmospheric gases or methane. Illustration by Gaspar Schott from “Experimenta nova (ut vocantur) Magdeburgica de vacuo spatio” (1672). Dr. G. Borsato is acknowledged for the artwork.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
    1. Graphical Abstract: Angew. Chem. Int. Ed. 26/2007 (pages 4803–4814)

      Article first published online: 15 JUN 2007 | DOI: 10.1002/anie.200790119

  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
  5. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
  6. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
    1. Magnetic Resonance at or below the Earth's Magnetic Field (pages 4820–4824)

      Christina M. Thiele

      Article first published online: 31 MAY 2007 | DOI: 10.1002/anie.200700730

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      NMR resonances of two nuclei can be obtained in one spectrum at ultralow magnetic fields. At such low fields, chemical shifts become negligible and heteronuclear couplings dominate the NMR spectra. The Highlight gives an overview of “pure J-coupling spectroscopy” and (functional) imaging applications at magnetic-field strengths in the range of the Earth's magnetic field.

    2. A Long Research Story Culminates in the First Total Synthesis of Moenomycin A (pages 4825–4829)

      Peter Welzel

      Article first published online: 5 JUN 2007 | DOI: 10.1002/anie.200700765

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      The highly active inhibitor of the “forgotten” transglycosylases, moenomycin A, succumbed to total synthesis. The pentasaccharide backbone was constructed employing sulfoxides as glycosyl donors. The recent moenomycin results should establish it as a promising lead structure for new antiinfectives.

  7. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
    1. Discotic Liquid Crystals: From Tailor-Made Synthesis to Plastic Electronics (pages 4832–4887)

      Sabine Laschat, Angelika Baro, Nelli Steinke, Frank Giesselmann, Constanze Hägele, Giusy Scalia, Roxana Judele, Elisabeth Kapatsina, Sven Sauer, Alina Schreivogel and Martin Tosoni

      Article first published online: 14 JUN 2007 | DOI: 10.1002/anie.200604203

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      Well stacked? The broad structural diversity and columnar orientation in the liquid-crystalline phase provides access to a variety of potential applications of columnar liquid crystals, such as organic light-emitting diodes (see picture), photovoltaic cells, field-effect transistors, or photoconducting materials in laser printers.

  8. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
    1. Trifluoro-1,3,5-tridehydrobenzene (pages 4888–4893)

      Sugumar Venkataramani, Michael Winkler and Wolfram Sander

      Article first published online: 14 JUN 2007 | DOI: 10.1002/anie.200700536

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      Three stay, three go: Flash vacuum pyrolysis (FVP) of 1 and subsequent trapping of the products in solid argon at 3 K produces trifluoro-1,3,5-tridehydrobenzene (2). IR spectroscopy, the photochemical behavior, and quantum chemical calculations confirm that for the first time a derivative of the elusive 1,3,5-tridehydrobenzene could be isolated and spectroscopically characterized.

    2. F Centers versus Dimer Vacancies on ZnO Surfaces: Characterization by STM and STS Calculations (pages 4894–4897)

      Roman Kováčik, Bernd Meyer and Dominik Marx

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200604399

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      Not what you'd expect: Contrary to what is usually believed for oxide surfaces, density functional calculations show that not F centers but missing ZnO dimers are the thermodynamically most favorable type of atomic defect on the nonpolar ZnO surface. Simulated STM data may serve as a fingerprint for experimental identification of the different surface defect types. The picture shows a tunneling tip over ZnO (Zn gray, O red, W blue) with the corresponding STM image in between.

    3. Chivosazole A—Elucidation of the Absolute and Relative Configuration (pages 4898–4901)

      Dominic Janssen, Dieter Albert, Rolf Jansen, Rolf Müller and Markus Kalesse

      Article first published online: 15 MAY 2007 | DOI: 10.1002/anie.200605198

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      The best of both worlds: The configurational assignment of a natural product—chivosazole A (1) isolated from myxobacteria—has been achieved for the first time through the combination of structure elucidation and genetic analysis. This was achieved by chemical degradation, analysis of the NMR data in combination with computer-aided conformation analysis, and assignment of the amino acid sequence.

    4. Stabilization of Tetrafluorobutatriene by Complex Formation (pages 4902–4904)

      Floris A. Akkerman and Dieter Lentz

      Article first published online: 18 MAY 2007 | DOI: 10.1002/anie.200701081

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      Now tamed: For decades preparative research on 1,1,4,4-tetrafluorobutatriene was not pursued because of the explosive nature of the compound. Two new transition-metal complexes containing a tetrafluorobutatriene ligand (see picture; green F/Cl, gray C, red O, purple P, orange Ir/Rh) have been prepared from the free triene, and both complexes are air-stable.

    5. A 1,8-Naphthylene-Bridged Bis(indenyl)zinc THF Adduct: Formation and Structure of an ansa-Zincocene Derivative (pages 4905–4908)

      Huadong Wang, Gerald Kehr, Roland Fröhlich and Gerhard Erker

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200605069

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      Zinc has the ansa: Deprotonation of the ligand 1,8-bis(indenyl)naphthalene followed by treatment with ZnCl2 gives an ansa-zincocene. Its crystal structure reveals a σ/(σ,π) coordination of the indenyl units to the central zinc atom (see structure; C white, O red, Zn blue).

    6. Covalently Functionalized Cobalt Nanoparticles as a Platform for Magnetic Separations in Organic Synthesis (pages 4909–4912)

      Robert N. Grass, Evagelos K. Athanassiou and Wendelin J. Stark

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200700613

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      Synthesis in a day! Carbon-coated metal nanoparticles can be covalently functionalized by diazonium chemistry. These colloidal reagents can now serve as a basis to magnetically functionalize molecules during synthesis, enabling their recovery within seconds.

    7. Microfluidic Glass Chips with an Integrated Nanospray Emitter for Coupling to a Mass Spectrometer (pages 4913–4916)

      Peter Hoffmann, Ulrich Häusig, Philipp Schulze and Detlev Belder

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200605152

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      A coupling coup: A novel microfluidic chip with an integrated nanospray emitter enables the first dead-volume-free coupling of glass-chip laboratories with mass spectrometry. An electrophoretic version of the system may be suitable for the separation and analysis of drugs, for example, and has potential for the high-throughput analysis of miniscule amounts of samples.

    8. Trimeric Clusters of Silver in Aqueous AgNO3 Solutions and Their Role as Nuclei in Forming Triangular Nanoplates of Silver (pages 4917–4921)

      Yujie Xiong, Isao Washio, Jingyi Chen, Martin Sadilek and Younan Xia

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200700942

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      Three's a crowd: Trimeric silver clusters in aqueous AgNO3 solutions have been identified by mass spectrometry (see picture). These clusters are found to dominate nucleation and thus play an important role in the formation of triangular silver nanoplates, which are shown in the SEM image in the lower right part of the picture.

    9. Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic, Tandem Michael/Henry Reaction for the Control of Four Stereocenters (pages 4922–4925)

      Yujiro Hayashi, Tsubasa Okano, Seiji Aratake and Damien Hazelard

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200700909

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      A choice of three: The tandem Michael/Henry reaction of a nitroalkene and pentane-1,5-dial (generated in situ) proceeded efficiently when diphenylprolinol silyl ether was used as an organocatalyst to afford substituted nitrocyclohexanecarbaldehydes with high diastereo- and enantioselectivity (see scheme; TMS: trimethylsilyl). Isomerization under basic or acidic conditions diastereoselectively converts the product into two stereoisomers, without compromising the enantioselectivity.

    10. The Chemical Mechanism of D-1-Deoxyxylulose-5-phosphate Reductoisomerase from Escherichia coli (pages 4926–4929)

      Ursula Wong and Russell J. Cox

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200700647

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      Find the way: 3-[2H]- and 4-[2H]-labeled 1-deoxyxylulose-5-phosphate were synthesized and used to investigate the chemical mechanism of 1-deoxyxylulose-5-phosphate reductoisomerase (DXR) from E. coli. The observation of inverse secondary kinetic isotope effects for both labeled substrates indicates that DXR uses a retro-aldol/aldol mechanism in which the recombination reaction is the rate-limiting step (see scheme).

    11. Formation of an Aza-nickelacycle by Reaction of an Imine and an Alkyne with Nickel(0): Oxidative Cyclization, Insertion, and Reductive Elimination (pages 4930–4932)

      Sensuke Ogoshi, Haruo Ikeda and Hideo Kurosawa

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200700688

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      Cyclize, add, reduce: The oxidative cyclization of an imine and an alkyne with nickel(0) followed by the insertion of a second alkyne gives a seven-membered aza-nickelacycle (see scheme). Subsequent reductive elimination yields a 1,2-dihydropyridine. This sequential reaction process is expanded to a one-step nickel-catalyzed [2+2+2] cycloaddition of two alkynes and an imine.

    12. Stereoselective Monofluoromethylation of Primary and Secondary Alcohols by Using a Fluorocarbon Nucleophile in a Mitsunobu Reaction (pages 4933–4936)

      G. K. Surya Prakash, Sujith Chacko, Steevens Alconcel, Timothy Stewart, Thomas Mathew and George A. Olah

      Article first published online: 23 MAY 2007 | DOI: 10.1002/anie.200700834

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      OH is exchanged: An efficient Mitsunobu reaction that uses a fluorinated carbon pronucleophile for the facile synthesis of monofluoromethyl derivatives of alcohols is reported (see scheme; DIAD=diisopropyl azodicarboxylate). This reaction can be performed under mild conditions and is highly feasible for primary, secondary, allylic, benzylic, and alicyclic alcohols. Excellent enantiospecificity is observed for chiral alcohols.

    13. Rhodium-Catalyzed Aryl Transfer from Trisubstituted Aryl Methanols to α,β-Unsaturated Carbonyl Compounds (pages 4937–4939)

      Takahiro Nishimura, Taisuke Katoh and Tamio Hayashi

      Article first published online: 16 MAY 2007 | DOI: 10.1002/anie.200700902

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      A process of elimination: The rhodium-catalyzed arylation of α,β-unsaturated carbonyl compounds with 9-aryl-10-benzyl-9,10-dihydroacridin-9-ols 1 as arylating reagents proceeds efficiently via β-aryl elimination of the rhodium alkoxide intermediates, to give the 1,4-addition products in high yields (see scheme; Bn=benzyl, cod=cycloocta-1,5-diene).

    14. 10a-Aza-10b-borapyrenes: Heterocyclic Analogues of Pyrene with Internalized BN Moieties (pages 4940–4943)

      Michael J. D. Bosdet, Warren E. Piers, Ted S. Sorensen and Masood Parvez

      Article first published online: 5 APR 2007 | DOI: 10.1002/anie.200700591

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      Très BN: The introduction of a B[BOND]N dipole into the internal positions of pyrene (see scheme) provides a novel platform for heterocyclic fluorescent species. Comparisons of the photophysical and redox properties between the CC and BN analogues reveal both similarities and differences.

    15. Surface-Plasmon-Enhanced Fluorescence Spectroscopy for DNA Detection Using Fluorescently Labeled PNA as “DNA Indicator” (pages 4944–4947)

      Li-Qiang Chu, Renate Förch and Wolfgang Knoll

      Article first published online: 18 MAY 2007 | DOI: 10.1002/anie.200605247

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      A homogeneous sensor: A new method for the detection of DNA is described. The approach is based on the high surface sensitivity provided by surface-plasmon-enhanced fluorescence spectroscopy and on the different electrostatic properties of peptide nucleic acids (PNAs) and DNA (see scheme). Immobilization of the DNA probes on the sensor surface is not required, which may reduce the complexity and costs of sensor preparation.

    16. Superoxide Does React with Peroxides: Direct Observation of the Haber–Weiss Reaction in the Gas Phase (pages 4948–4950)

      Stephen J. Blanksby, Veronica M. Bierbaum, G. Barney Ellison and Shuji Kato

      Article first published online: 18 MAY 2007 | DOI: 10.1002/anie.200700219

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      Radically speaking: Reactions of superoxide with hydrogen peroxide and organic hydroperoxide compounds are observed as efficient processes in the gas phase and yield products—including the ozonide anion—that are consistent with the one-electron reduction of the peroxide species (see scheme).

    17. One-Pot Synthesis of Manganese Oxide Nanosheets in Aqueous Solution: Chelation-Mediated Parallel Control of Reaction and Morphology (pages 4951–4955)

      Yuya Oaki and Hiroaki Imai

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200700244

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      Sheet materials: Manganese oxide nanosheets and their oriented thin films can be prepared by a bottom-up approach in aqueous solution under ambient conditions (left). Chelation between the manganese species and ethylenediaminetetraacetate (EDTA) ligands results in birnessite-type nanosheets (see micrographs and diffraction pattern). The biomimetic pathway allows simultaneous control of synthesis and morphogenesis by the EDTA chelating agent.

    18. Suzuki Polycondensation Put to Work: A Tough Poly(meta-phenylene) with a High Glass-Transition Temperature (pages 4956–4959)

      Ramchandra Kandre, Kirill Feldman, Han E. H. Meijer, Paul Smith and A. Dieter Schlüter

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200700966

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      Challenging commercial polycarbonate: Suzuki polycondensation afforded a high-molar-mass poly(meta-phenylene) (see structure) which displays not only outstanding toughness, convenient processability, and a high glass-transition temperature, but also considerable resistance against environmental stress-cracking; thus, it rivals high-performance polycarbonate in its fundamental properties.

    19. Interactions of Microcrystals through Free Pyridyl Groups: Microcross and Chain-Arrayed Supercrystals of a Palladium(II) Complex (pages 4960–4963)

      In Sung Chun, Jung Ah Kwon, Hye Ji Yoon, Myung Nam Bae, Jongki Hong and Ok-Sang Jung

      Article first published online: 16 MAY 2007 | DOI: 10.1002/anie.200701152

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      Crosses or chains? The two free pyridyl groups of a dimeric, triethanolamine-triisonicotinate-bridged palladium complex allow the formation of a unique microcross morphology or chain array of microcrystals (see picture), depending on the reaction conditions. These morphologies arise from interactions between microcrystals involving hydrogen bonding of the free pyridyl groups on the microcrystal surface and water molecules.

    20. CuI-Catalyzed Conjugate Addition of Ethyl Propiolate (pages 4964–4967)

      Shinji Fujimori and Erick M. Carreira

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200701098

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      More functionality possible: The conjugate addition of ethyl propiolate to Meldrum's acid derived acceptors is described. These reactions proceed under mild conditions employing substoichiometric amounts of a copper(I) species generated in situ. When chiral acceptors are employed as substrates, the additions are stereoselective and provide the addition adduct with high diastereoselectivity.

    21. Reactivity of “Frustrated Lewis Pairs”: Three-Component Reactions of Phosphines, a Borane, and Olefins (pages 4968–4971)

      Jenny S. J. McCahill, Gregory C. Welch and Douglas W. Stephan

      Article first published online: 25 MAY 2007 | DOI: 10.1002/anie.200701215

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      All or nothing: Sterically frustrated Lewis pairs of phosphines and the borane B(C6F5)3 exhibit unprecedented reactivity with olefins to afford both inter- and intramolecular alkanediyl-linked phosphonium borates (see picture; black C, pink F, green B, orange P). These reactions are all the more remarkable given that any pair of these reagents do not react while the combination of all three reagents results in product formation.

    22. Gas Hosting in Enantiopure Self-Assembled Oximes (pages 4972–4975)

      Alessandro Scarso, Leonardo Pellizzaro, Ottorino De Lucchi, Anthony Linden and Fabrizio Fabris

      Article first published online: 8 MAY 2007 | DOI: 10.1002/anie.200701123

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      Trapped gas: The enantiopure C3-symmetric trioxime derived from (+)-syn-benzotricamphor forms a dimer in low-polar solvents which encapsulates small molecules, such as Ar, CO, O2, N2, and CH4 (see picture; gray C, blue N, red O, white H). The two benzocyclotrimers are fastened together by six hydrogen bonds between the oxime moieties. Gas binding is fast on the NMR timescale at room temperature, but is slow and complete at lower temperature.

    23. Second-Order Jahn–Teller Effect in a Host–Guest Complex (pages 4976–4978)

      Bryan E. F. Tiedemann and Kenneth N. Raymond

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200701002

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      A quick in and out: A supramolecular cluster encapsulates a cation guest with a linear alkyl side chain, which rapidly extends and retracts through apertures in the triangular faces of the tetrahedral host. This motion results in a dynamic second-order Jahn–Teller distortion (see picture).

    24. Synthesis and Characterization of Tantalum(V) Boronate Clusters: Multifunctional Lewis Acid Cages for Binding Guests (pages 4979–4982)

      Olivier Sigouin, Christian N. Garon, Gille Delaunais, Xilin Yin, Tom K. Woo, Andreas Decken and Frédéric-Georges Fontaine

      Article first published online: 21 MAY 2007 | DOI: 10.1002/anie.200700801

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      Open and shut cases: Tantalum(V) boronate clusters [(Cp*Ta)322-RBO2)32-O)22-OH)(μ3-OH)] (Cp*=η5-C5Me5; 1: R=Ph, 2: R=iBu) with Lewis acidic cavities were prepared. Whereas the cavity of 2 is blocked by the iBu groups, that of 1 is open and can bind Lewis basic guests such as ketones (see picture) by interaction with one boronate and one μ3-OH ligand.

    25. A Crystalline Supramolecular Switch: Controlling the Optical Anisotropy through the Collective Dynamic Motion of Molecules (pages 4983–4986)

      Masaki Horie, Takafumi Sassa, Daisuke Hashizume, Yuji Suzaki, Kohtaro Osakada and Tatsuo Wada

      Article first published online: 25 MAY 2007 | DOI: 10.1002/anie.200700708

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      Going 'round the twist: Single crystals of a ferrocenyl-substituted pseudorotaxane have different structures at 30 and 128 °C owing to a thermal crystalline phase transition. This change in crystal structure results from a conformational change that involves rotation of the aromatic ring of the axle component (see scheme), and cooperative unidirectional rotation of the molecules alters the optical anisotropy of the crystal.

    26. Topotactic Linear Radical Polymerization of Divinylbenzenes in Porous Coordination Polymers (pages 4987–4990)

      Takashi Uemura, Daisuke Hiramatsu, Yoshiki Kubota, Masaki Takata and Susumu Kitagawa

      Article first published online: 18 MAY 2007 | DOI: 10.1002/anie.200700242

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      In the groove: Radical polymerization of divinylbenzenes (DVBs) in the one-dimensional nanochannels of porous coordination polymers allows linearly extended topotactic polymerization without cross-linking (see picture). The main factors that influence this polymerization are the channel size and host framework flexibility.

    27. Remote Radio-Frequency Controlled Nanoliter Chemistry and Chemical Delivery on Substrates (pages 4991–4994)

      Hongke Ye, Christina L. Randall, Timothy G. Leong, Daniel A. Slanac, Emma K. Call and David H. Gracias

      Article first published online: 16 MAY 2007 | DOI: 10.1002/anie.200604414

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      A matter of control: Metallic, self-assembled nanoliter containers have been prepared that can be remotely guided in any chosen spatial trajectory by a magnetic field, as well as remotely triggered by radio-frequency electromagnetic fields to release chemical reactants (see picture). The containers were utilized to facilitate, on demand, spatially localized microfabrication in a capillary and non-invasive chemical delivery to living cells.

    28. Directed Assembly of Cluster-Based Supramolecules into One-Dimensional Coordination Polymers (pages 4995–4998)

      Jian-Jun Zhang, Hua-Jun Zhou and Abdessadek Lachgar

      Article first published online: 5 APR 2007 | DOI: 10.1002/anie.200604268

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      From five to infinity: The pentameric cluster-based supramolecular units {[Mn(L)]4[Nb6Cl12(CN)6]} (H2L=7-Me-salen) can be extended into two 1D coordination polymers through either the formation of manganese dimers or through ditopic ligands (see picture). In 1 the supramolecular units are linked through phenoxo bridges between the Mn complexes, while in 2 a trans-1,2-bis(4-pyridyl)ethylene ligand connects the pentameric assemblies.

    29. Targeted Charge-Reversal Nanoparticles for Nuclear Drug Delivery (pages 4999–5002)

      Peisheng Xu, Edward A. Van Kirk, Yihong Zhan, William J. Murdoch, Maciej Radosz and Youqing Shen

      Article first published online: 25 MAY 2007 | DOI: 10.1002/anie.200605254

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      Reversing the charges: Targeted charge-reversal nanoparticles (TCRNs) comprised of poly(ε-caprolactone)-block-polyethyleneimine (PCL-PEI), whose amine groups are converted into amides, are negatively charged at neutral pH but become positively charged at pH<6 (see picture). TCRNs effectively enter cells, regenerate the PEI layer in lysosomes, and localize in the nucleus for nuclear drug delivery.

    30. Mesoporous Organic–Inorganic Hybrid Materials Built Using Polyhedral Oligomeric Silsesquioxane Blocks (pages 5003–5006)

      Lei Zhang, Hendrikus C. L. Abbenhuis, Qihua Yang, Yi-Meng Wang, Pieter C. M. M. Magusin, Brahim Mezari, Rutger A. van Santen and Can Li

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200700640

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      Rounding up the POSSe: Polyhedral oligomeric silsesquioxanes (POSS), one of the smallest hybrid nano building blocks, were weaved into multifunctional hierarchical mesoporous hybrid materials. The mesoporous organic–inorganic hybrid material was synthesized by coassembly and condensation of the POSS compound around the block copolymer P123 micelles and subsequent release of the porogen (see scheme), resulting in a uniform pore size of 4.40 nm.

    31. Metallodynamers: Neutral Dynamic Metallosupramolecular Polymers Displaying Transformation of Mechanical and Optical Properties on Constitutional Exchange (pages 5007–5010)

      Cheuk-Fai Chow, Shunsuke Fujii and Jean-Marie Lehn

      Article first published online: 25 MAY 2007 | DOI: 10.1002/anie.200700727

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      Mix and match: Neutral dynamic metallosupramolecular polymers (metallodynamers) derived from acylhydrazone-based metal coordination centers exchange and reshuffle their components through ligand exchange at the metal coordination site, even in the absence of solvent and catalyst, to modify their constitution. As a result, the materials undergo remarkable changes in both their mechanical and optical properties (see picture).

    32. Tetraarylphosphonium Salts as Soluble Supports for the Synthesis of Small Molecules (pages 5011–5014)

      Federica Stazi, David Marcoux, Jean-Christophe Poupon, Daniel Latassa and André B. Charette

      Article first published online: 22 MAY 2007 | DOI: 10.1002/anie.200700833

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      Support groups: Phosphonium salts can be used as solubility-control groups (SCGs) in small-molecule and peptide synthesis (see scheme). The concept, which is a hybrid approach between solution- and solid-phase syntheses, is illustrated by the preparation of 2-substituted piperidine derivatives and a variety of small peptides with high yields and purities. In some cases, recycling of the support is possible.

    33. One Template, Multiple Rings: Controlled Iterative Addition of Macrocycles onto a Single Binding Site Rotaxane Thread (pages 5015–5019)

      Anne-Marie L. Fuller, David A. Leigh and Paul J. Lusby

      Article first published online: 25 MAY 2007 | DOI: 10.1002/anie.200700933

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      One for all: The iteration of three simple steps—complexation, macrocyclization, and demetalation—enables the synthesis of multi-ring rotaxanes with only one template site (see picture). This efficient and effective strategy enables both the number and the order in which macrocycles are assembled onto a thread to be controlled with unprecedented precision.

    34. N-Phosphino Sulfinamide Ligands: An Efficient Manner To Combine Sulfur Chirality and Phosphorus Coordination Behavior (pages 5020–5023)

      Jordi Solà, Marc Revés, Antoni Riera and Xavier Verdaguer

      Article first published online: 24 MAY 2007 | DOI: 10.1002/anie.200701040

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      Four in a row: Four linked heteroatoms (P-N-S-O) constitute the backbone of N-phosphino tert-butylsulfinamides, a novel class of chiral ligands (see picture, P yellow, N blue, S magenta, O red). Carbon substituents surrounding the central heteroatomic spine transmit the chirality of the sulfur center throughout the ligand. As bidentate P,S ligands in dicobalt–alkyne complexes, they can be used in the asymmetric intermolecular Pauson–Khand reaction.

    35. Imidazolyl Cyclodextrins: Artificial Serine Proteases Enabling Regiospecific Reactions (pages 5024–5027)

      De-Qi Yuan, Yumika Kitagawa, Keisuke Aoyama, Toshihiko Douke, Makoto Fukudome and Kahee Fujita

      Article first published online: 16 MAY 2007 | DOI: 10.1002/anie.200701156

      Thumbnail image of graphical abstract

      Remote control: The imidazolyl group in a series of imidazolyl cyclodextrins guides the sulfonylation of a specific hydroxy group in the presence of many others to effect a regioselective 1,22 remote functionalization (see structure; Mess=mesitylenesulfonyl, n=0–2). This process enables the establishment of a novel efficient strategy for the hetero-bifunctionalization and -trifunctionalization of cyclodextrins.

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      Preview: Angew. Chem. Int. Ed. 27/2007 (page 5031)

      Article first published online: 15 JUN 2007 | DOI: 10.1002/anie.200790121

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