Development of a T1 Contrast Agent for Magnetic Resonance Imaging Using MnO Nanoparticles (pages 5397–5401)
Hyon Bin Na, Jung Hee Lee, Kwangjin An, Yong Il Park, Mihyun Park, In Su Lee, Do-Hyun Nam, Sung Tae Kim, Seung-Hoon Kim, Sang-Wook Kim, Keun-Ho Lim, Ki-Soo Kim, Sun-Ok Kim and Taeghwan Hyeon
Article first published online: 13 MAR 2007 | DOI: 10.1002/anie.200604775
Contrasting images: A new T1 contrast agent for magnetic resonance imaging (MRI) based on MnO nanoparticles reveals a bright signal enhancement and fine anatomic structures in the T1-weighted MR image of a mouse brain (see picture; left MRI, right MnO-enhanced MRI (MONEMRI)). Furthermore, MnO nanoparticles conjugated with a tumor-specific antibody were used for selectively imaging breast cancer cells in a metastatic tumor in brain.