Angewandte Chemie International Edition

Cover image for Vol. 46 Issue 3

January 8, 2007

Volume 46, Issue 3

Pages 309–473

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
    1. Cover Picture: Secondary Structure, Dynamics, and Topology of a Seven-Helix Receptor in Native Membranes, Studied by Solid-State NMR Spectroscopy (Angew. Chem. Int. Ed. 3/2007) (page 309)

      Manuel Etzkorn, Swetlana Martell, Ovidiu C. Andronesi, Karsten Seidel, Martin Engelhard and Marc Baldus

      Article first published online: 27 DEC 2006 | DOI: 10.1002/anie.200690175

      Membrane proteins can now be studied in their native environments by using high-resolution solid-state NMR spectroscopy. Techniques that probe rigid, mobile, and water-exposed protein segments provide insight into the membrane-embedded structure of sensory rhodopsin II from Natronomonas pharaonis. The secondary structure, dynamics, and membrane topology of this seven-helix receptor are discussed by M. Engelhard, M. Baldus, and co-workers in their Communication on page 459 ff.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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    1. Inside Cover: Oligothiophene-Based Catenanes: Synthesis and Electronic Properties of a Novel Conjugated Topological Structure (Angew. Chem. Int. Ed. 3/2007) (page 310)

      Peter Bäuerle, Martin Ammann, Markus Wilde, Günther Götz, Elena Mena-Osteritz, Alexander Rang and Christoph A. Schalley

      Article first published online: 11 JAN 2007 | DOI: 10.1002/anie.200790006

      A “π-conjugated catenane” or more accurately a catenane formed from two intertwined conjugated macrocycles has been formed for the first time by a double metal template strategy. Interestingly, a through-space electronic interaction between the donor unit (oligothiophene, metallic color) and the acceptor component of the other ring (phenanthroline, blue) is evident. Further details can be found in the Communication by P. Bäuerle et al. on page 363ff.

  3. Graphical Abstract

    1. Top of page
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    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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    1. Graphical Abstract: Angew. Chem. Int. Ed. 3/2007 (pages 313–321)

      Article first published online: 27 DEC 2006 | DOI: 10.1002/anie.200690176

  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
  5. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
    10. Preview
  6. Highlights

    1. Top of page
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    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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    1. Cyaphide (C[TRIPLE BOND]P): The Phosphorus Analogue of Cyanide (C[TRIPLE BOND]N) (pages 330–332)

      Robert J. Angelici

      Article first published online: 8 DEC 2006 | DOI: 10.1002/anie.200603724

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      An up-and-coming sibling: Unlike the cyanide ion (C[TRIPLE BOND]N), which is one of the fundamental ions in inorganic chemistry, cyaphide (C[TRIPLE BOND]P) is not stable unless it is coordinated to a metal center, either as a bridging ligand or, as just recently demonstrated, as a terminal ligand (see scheme; L=monodentate phosphane, X=halide).

    2. Novel Olefin Block Copolymers through Chain-Shuttling Polymerization (pages 333–335)

      Manuela Zintl and Bernhard Rieger

      Article first published online: 8 DEC 2006 | DOI: 10.1002/anie.200602889

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      Shuttle chain in operation: “Chain-shuttling” polymerization is a promising strategy for the synthesis of high-performance polyolefins. Polymerization takes place block by block using two different catalysts to generate new block copolymers with special properties.

  7. Review

    1. Top of page
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    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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    1. Phosphate Recognition in Structural Biology (pages 338–352)

      Anna K. H. Hirsch, Felix R. Fischer and François Diederich

      Article first published online: 12 DEC 2006 | DOI: 10.1002/anie.200603420

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      Filled pockets: The most important interactions involved in biological phosphate recognition have been characterized. From 3003 considered structures, 2456 feature phosphate binding sites (as shown in the picture; ligand skeleton green, C gray, O red, N blue, P orange) without metal ions. The search reveals similarities to phosphate binding by synthetic receptors and points to new approaches for filling phosphate sites in drug-discovery research.

  8. Communications

    1. Top of page
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    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
    9. Communications
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    1. Chiral Neutral Zirconium Amidate Complexes for the Asymmetric Hydroamination of Alkenes (pages 354–358)

      Mark C. Wood, David C. Leitch, Charles S. Yeung, Jennifer A. Kozak and Laurel L. Schafer

      Article first published online: 9 OCT 2006 | DOI: 10.1002/anie.200603017

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      Aminations with amidates: The first C2-symmetric amidate complexes of zirconium were used for catalytic asymmetric hydroaminations of amino alkenes to prepare chiral gem-disubstituted pyrrolidines with up to 93 % ee (see scheme). The modular nature of the chiral complexes facilitates their preparation and screening as catalysts.

      Corrected by:

      Corrigendum: Corrigendum: Chiral Neutral Zirconium Amidate Complexes for the Asymmetric Hydroamination of Alkenes

      Vol. 49, Issue 37, 6475, Article first published online: 1 SEP 2010

      Corrected by:

      Corrigendum: Chiral Neutral Zirconium Amidate Complexes for the Asymmetric Hydroamination of Alkenes

      Vol. 48, Issue 38, 6937, Article first published online: 1 SEP 2009

    2. Asymmetric Synthesis of α-Substituted Allyl Boranes and Their Application in the Synthesis of Iso-agatharesinol (pages 359–362)

      Guang Yu Fang and Varinder K. Aggarwal

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603659

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      Use your borane: A stereocontrolled synthesis of allyl boranes from chiral sulfur ylides and their subsequent reaction with aldehydes to give homoallylic alcohols is described. The allyl boranes also could undergo a stereospecific 1,3-borotropic rearrangement to give another set of homoallylic alcohols (see scheme). The reaction has been applied to an efficient synthesis of iso-agatharesinol.

    3. Oligothiophene-Based Catenanes: Synthesis and Electronic Properties of a Novel Conjugated Topological Structure (pages 363–368)

      Peter Bäuerle, Martin Ammann, Markus Wilde, Günther Götz, Elena Mena-Osteritz, Alexander Rang and Christoph A. Schalley

      Article first published online: 31 OCT 2006 | DOI: 10.1002/anie.200602652

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      Make it a double: A double metal template strategy has been used to form a “π-conjugated catenane” consisting of intertwined macrocycles with oligothienyl and phenanthroline units (see calculated structure). The optical and redox properties as well as the structural and conformational analyses give clear evidence that the two macrocycles in the catenane influence each other by through-space donor–acceptor interactions.

    4. Synthesis and Properties of Oxygen-Centered Tetradecaimido Hexatantalum Clusters (pages 369–372)

      Jamin L. Krinsky, Laura L. Anderson, John Arnold and Robert G. Bergman

      Article first published online: 8 DEC 2006 | DOI: 10.1002/anie.200603019

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      A New Class of Metal–Imido Complex: Octahedral hexatantalum clusters [(ArN)14Ta6O] (see picture; C gray, N blue, O red, Ta orange, Ar=Ph) were formed in good yields by treatment of [Bn3Ta[DOUBLE BOND]NtBu] (Bn=benzyl) or [Ta(NMe2)5] with an excess of the appropriate aniline and an equivalent of water. Crystallographic analysis revealed the presence of a central oxygen atom, which was further identified by electrospray mass spectrometry using 17O/18O-enriched material.

    5. You have free access to this content
      Efficient Sensitization of Nanocrystalline TiO2 Films by a Near-IR-Absorbing Unsymmetrical Zinc Phthalocyanine (pages 373–376)

      Paidi Yella Reddy, Lingamallu Giribabu, Christopher Lyness, Henry J. Snaith, Challuri Vijaykumar, Malapaka Chandrasekharam, Mannepalli Lakshmikantam, Jun-Ho Yum, Kuppuswamy Kalyanasundaram, Michael Grätzel and Mohammad K. Nazeeruddin

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603098

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      Pushing and pulling by three tert-butyl and two carboxylic acid groups, respectively, results in a sensitizer (see picture) that exhibits an incident photon-to-current conversion efficiency of 75 %. A cell sensitized with this compound gives a short-circuit photocurrent density of (6.50±0.20) mA cm−2, an open-circuit voltage of (635±30) mV, and a fill factor of 0.74±0.03, which corresponds to an overall conversion efficiency of 3.05 %.

    6. [Mn(tmc)(O2)]+: A Side-On Peroxido Manganese(III) Complex Bearing a Non-Heme Ligand (pages 377–380)

      Mi Sook Seo, Ja Young Kim, Jamespandi Annaraj, Youngmee Kim, Yong-Min Lee, Sung-Jin Kim, Jinheung Kim and Wonwoo Nam

      Article first published online: 28 NOV 2006 | DOI: 10.1002/anie.200603414

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      On the side: The crystal structure of a peroxido MnIII complex bearing a non-heme ligand shows that the peroxide ligand is bound to a manganese ion symmetrically in a side-on η2 fashion. The complex is capable of deformylating aldehydes by a nucleophilic reaction but not capable of oxygenating substrates by an electrophilic reaction. tmc=1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane.

    7. How Can a Carbon Atom Be Covalently Bound to Five Ligands? The Case of Si2(CH3)7+ (pages 381–385)

      Juan Z. Dávalos, Rebeca Herrero, José-Luis M. Abboud, Otilia Mó and Manuel Yáñez

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200601164

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      The beauty of symmetry: The Si2(CH3)7+ ion can be observed under the low pressures used in Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. The optimized geometry of the ion, as determined from theoretical calculations and FT-ICR experimental results, reveals a C3h-symmetric structure, in which a planar CH3 group is symmetrically bonded to two eclipsed Si(CH3)3 moieties (see picture; Si blue, C dark gray, H pale gray).

    8. A Highly Regio- and Stereoselective Vinylogous Horner–Wadsworth–Emmons Route to Densely Substituted 1,3-Butadienes (pages 386–388)

      Sonali M. Date and Sunil K. Ghosh

      Article first published online: 28 NOV 2006 | DOI: 10.1002/anie.200604013

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      A new dimension has been given to the Horner–Wadsworth–Emmons reaction almost 50 years after its inception. In an unprecedented vinylogous version of the reaction, aldehydes and cyano-substituted vinyl phosphonates serve as substrates (see scheme). The novel transformations to form 1,3-dienes with a trisubstituted double bond exhibit very high regio- and stereoselectivities.

      Corrected by:

      Corrigendum: A Highly Regio- and Stereoselective Vinylogous Horner–Wadsworth–Emmons Route to Densely Substituted 1,3-Butadienes

      Vol. 46, Issue 14, 2348, Article first published online: 16 MAR 2007

    9. Highly Asymmetric Michael Addition to α,β-Unsaturated Ketones Catalyzed by 9-Amino-9-deoxyepiquinine (pages 389–392)

      Jian-Wu Xie, Wei Chen, Rui Li, Mi Zeng, Wei Du, Lei Yue, Ying-Chun Chen, Yong Wu, Jin Zhu and Jin-Gen Deng

      Article first published online: 8 DEC 2006 | DOI: 10.1002/anie.200603612

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      Michael–Michael–retro-Michael cascade reactions are promoted by the highly efficient organocatalyst 9-amino-9-deoxyepiquinine (1). The asymmetric direct vinylogous Michael addition of α,α-dicyanoalkenes to α,β-unsaturated ketones may be followed by an intramolecular Michael addition and a retro-Michael reaction to afford polysubstituted 2-cyclohexen-1-one derivatives with high enantioselectivity (see example).

      Corrected by:

      Corrigendum: Highly Asymmetric Michael Addition to α,β-Unsaturated Ketones Catalyzed by 9-Amino-9-deoxyepiquinine

      Vol. 46, Issue 27, 5049, Article first published online: 22 JUN 2007

    10. Evidence of Asymmetric Autocatalysis in Organocatalytic Reactions (pages 393–396)

      Michael Mauksch, Svetlana B. Tsogoeva, Irina M. Martynova and Shengwei Wei

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603517

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      When product and catalyst are the same: The chiral product 3 of an asymmetric Mannich reaction (see scheme), investigated under various experimental conditions and by calculations, is shown to act as a chiral catalyst for its own formation (autocatalysis). A generally applicable catalytic cycle is proposed to involve equilibria between hydrogen-bonded substrate–product complexes.

    11. Asymmetric Synthesis of Isomerically Pure Allenyl Boranes from Alkynyl Boranes through a 1,2-Insertion–1,3-Borotropic Rearrangement (pages 397–399)

      Eda Canales, Ana Z. Gonzalez and John A. Soderquist

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603467

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      Razzle-dazzle… and allenyl boranes 1 are obtained in enantiomerically pure form from 2 through a novel CHTMS insertion followed by a sterically driven suprafacial 1,3-borotropic rearrangement. Asymmetric allenylboration with 1 gives syn β-trimethylsilyl (TMS) homopropargylic alcohols 3 in 80–96 % yield with d.r. 99:1 and 94–99 % ee. When R=isopropenyl, allylboration occurs to provide the 1,2,3-trienyl alcohol 4 with >99 % ee.

    12. Substrate Modulation of the Activity of an Artificial Nanoesterase Made of Peptide-Functionalized Gold Nanoparticles (pages 400–404)

      Paolo Pengo, Lars Baltzer, Lucia Pasquato and Paolo Scrimin

      Article first published online: 28 NOV 2006 | DOI: 10.1002/anie.200602581

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      Nanozymes with a heart of gold: A functional artificial protein has been prepared by grafting a dodecapeptide onto the surface of gold nanoparticles (see picture). The system catalyzes the hydrolysis of carboxylate esters and features enzyme-like properties.

    13. Ab Initio Calculations of Absorption Spectra of Large Molecules in Solution: Coumarin C153 (pages 405–408)

      Roberto Improta, Vincenzo Barone and Fabrizio Santoro

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200602907

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      Shapes changed by solvent: An ab initio method for calculating the absorption spectra of large molecules including solvent effects and molecular vibrations shows how the solvent can shift the spectra and modulate their shapes (see picture; black lines: stick representation of absorption spectrum). The computed spectra of coumarin C153 in various solvents agree with the experimental ones.

    14. Bismuth-Catalyzed Direct Substitution of the Hydroxy Group in Alcohols with Sulfonamides, Carbamates, and Carboxamides (pages 409–413)

      Hongbo Qin, Noriyuki Yamagiwa, Shigeki Matsunaga and Masakatsu Shibasaki

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200602909

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      No preactivation of the alcohol substrates is required in allylic, propargylic, and benzylic aminations catalyzed by a combination of commercially available Bi(OTf)3 and KPF6, mostly at room temperature (see scheme). The substitution reactions of readily accessible allylic, propargylic, and benzylic alcohols with sulfonamides, carbamates, and carboxamides give the desired amine products in up to 99 % yield.

    15. Quantum Chemical Modeling and Preparation of a Biomimetic Photochemical Switch (pages 414–420)

      Flavio Lumento, Vinicio Zanirato, Stefania Fusi, Elena Busi, Loredana Latterini, Fausto Elisei, Adalgisa Sinicropi, Tadeusz Andruniów, Nicolas Ferré, Riccardo Basosi and Massimo Olivucci

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200602915

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      Designing and testing biomimetic switches: Multireference perturbation theory is used to model a light-driven molecular switch featuring the same photoisomerization mechanism as the chromophore of the visual pigment rhodopsin (see picture; QM/MM: quantum mechanics/molecular mechanics). By exploiting a synthetic route based on nitrilium-cation cyclization, it was shown that the designed system can indeed be prepared and characterized.

    16. Environmentally Friendly and Highly Sensitive Ruthenium(II) Tris(2,2′-bipyridyl) Electrochemiluminescent System Using 2-(Dibutylamino)ethanol as Co-Reactant (pages 421–424)

      Xiaoqing Liu, Lihong Shi, Wenxin Niu, Haijuan Li and Guobao Xu

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603491

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      Electric light orchestra: The electrochemiluminescence (ECL) intensity of the [Ru(bpy)3]2+/2-(dibutylamino)ethanol (DBAE) system at Au and Pt electrodes are about 10 and 100 times, respectively, greater than that of the commonly used [Ru(bpy)3]2+/tripropylamine (TPA) system (see picture). Thus, DBAE is a promising co-reactant for [Ru(bpy)3]2+ ECL immunoassays and DNA probe assays.

    17. Thermally Induced Cyclobutenone Rearrangements and Domino Reactions (pages 425–428)

      David C. Harrowven, David D. Pascoe and Ian L. Guy

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603538

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      Four thermal-rearrangement pathways and a domino reaction leading to quinones arise from the thermolysis of cyclobutenones. The course of vinylcyclobutenone rearrangements is dictated by the nature of the substituent, R (see scheme): a cyclopentenone arises when R is an electron-rich alkene. In other cases thermolysis gives a cyclohexadienone, which may collapse with elimination to form a quinone, or tautomerize into a hydroquinone or cyclohexenedione.

    18. Formation and Structure of a Sterically Protected Molybdenum Hydride Complex with a 15-Electron Configuration: [(1,2,4-C5H2tBu3)Mo(PMe3)2H]+ (pages 429–432)

      Miguel Baya, Jennifer Houghton, Jean-Claude Daran and Rinaldo Poli

      Article first published online: 28 NOV 2006 | DOI: 10.1002/anie.200603628

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      Got to get up to get down: Oxidation of [(1,2,4-C5H2tBu3)Mo(PMe3)2H3] induces H2 reductive elimination and yields the first stable 15-electron molybdenum hydride complex, [(1,2,4-C5H2tBu3)Mo(PMe3)2H]+ (see picture). The stability of this complex can be attributed to steric protection, as no additional electron density is available on the ligands for a π-stabilization mechanism.

    19. Enantioselective Total Synthesis of (+)-Homochelidonine by a PdII-Catalyzed Asymmetric Ring-Opening Reaction of a meso-Azabicyclic Alkene with an Aryl Boronic Acid (pages 433–436)

      Helen A. McManus, Matthew J. Fleming and Mark Lautens

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603945

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      An efficient and highly convergent enantioselective synthesis of (+)-homochelidonine has been achieved (see scheme; Cbz=benzyloxycarbonyl, MOM=methoxymethyl) and relied on a new and powerful desymmetrizing ring-opening reaction of a meso-azabicycle with an aryl boronic acid. The route should allow access to other hexahydrobenzo[c]phenanthridine alkaloids.

    20. A Concise Total Synthesis of (±)-Vigulariol (pages 437–440)

      J. Stephen Clark, Stewart T. Hayes, Claire Wilson and Luca Gobbi

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603880

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      From the deep: Vigulariol has been efficiently synthesized in 20 steps and 4.0 % overall yield from commercially available starting materials. Key to the synthesis was the use of copper(II) hexafluoroacetylacetate [Cu(hfacac)2] to form the oxabicyclo[6.2.1]undecene system (see scheme; TBS=tert-butyldimethylsilyl). The strategy should provide access to other members of the cladiellin family.

    21. Evidence of an Equimolar C2H2–CO2 Reaction in the Synthesis of Carbon Nanotubes (pages 441–444)

      Arnaud Magrez, Jin W. Seo, Vladimir L. Kuznetsov and László Forró

      Article first published online: 5 DEC 2006 | DOI: 10.1002/anie.200603764

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      Meeting point: Carbon nanotubes (CNTs) are produced by an equimolar reaction between C2H2 and CO2 (see scheme). CO2 can be introduced as a gas or a carbonate support of the metal particles. When CaCO3 is used, the growth of a nanotube stems from the triple-point junction, which corresponds to the area surrounding the metal support interface where CO2, C2H2, and the support meet.

    22. Revisiting the Electronic Ground State of Copper Corroles (pages 445–448)

      Martin Bröring, Frédérique Brégier, Esther Cónsul Tejero, Christian Hell and Max C. Holthausen

      Article first published online: 28 NOV 2006 | DOI: 10.1002/anie.200603676

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      Back in the saddle: Copper corroles do not contain a CuIII ion, but rather a well-hidden CuII ion. A comparative crystallographic and theoretical study (see spin-density representation) of isostructural corroloid complexes with copper ions in different formal oxidation states suggests that the divalent state is stabilized through a saddling distortion of the corrole ligand.

    23. Trinuclear Cyanines (TNCs) Revisited: A New Class of Electrochromics by Intramolecular π/σ Switching (pages 449–453)

      Hermann John, Christoph Briehn, Johann Schmidt, Siegfried Hünig and Jürgen Heinze

      Article first published online: 8 DEC 2006 | DOI: 10.1002/anie.200602596

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      The Y-shaped π systems in trinuclear cyanines can, through a formal two-electron transfer, form a core methylenecyclopropane unit with three shorter, isolated π systems (see picture). Studies of the spectroelectrochemistry verify the reversibility of this redox reaction, which has an unusually pronounced electrochromism.

    24. Saccharide-Induced Peptide Conformation in Glycopeptides of the Recognition Region of LI-Cadherin (pages 454–458)

      Axel Kuhn and Horst Kunz

      Article first published online: 8 DEC 2006 | DOI: 10.1002/anie.200602494

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      The type and the size of the saccharide side chain can affect the conformation of the peptide portion of glycopeptides. This was shown by conformational analysis in solution for a series of glycoundecapeptides with systematically varied tumor-associated carbohydrate antigens of type A from the recognition region of the cell adhesion glycoprotein LI-cadherin (gray C, red O, blue N; the saccharide side chain is more intensely colored).

    25. Secondary Structure, Dynamics, and Topology of a Seven-Helix Receptor in Native Membranes, Studied by Solid-State NMR Spectroscopy (pages 459–462)

      Manuel Etzkorn, Swetlana Martell, Ovidiu C. Andronesi, Karsten Seidel, Martin Engelhard and Marc Baldus

      Article first published online: 26 SEP 2006 | DOI: 10.1002/anie.200602139

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      In the loop: High-resolution solid-state NMR spectroscopy is used to study the secondary structure, dynamics, and membrane topology of an entire seven-helix receptor, sensory rhodopsin II from Natronomonas pharaonis (see picture). The experiments are carried out on a single isotope-labeled sample in a native membrane environment.

    26. Molecular Dynamics Simulation of Benzene Diffusion in MOF-5: Importance of Lattice Dynamics (pages 463–466)

      Saeed Amirjalayer, Maxim Tafipolsky and Rochus Schmid

      Article first published online: 28 NOV 2006 | DOI: 10.1002/anie.200601746

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      Doing the locomotion: When benzene molecules diffuse through the metal organic framework MOF-5, they accumulate in pockets (see picture). Molecular dynamics simulations reveal that the correlated lattice motion increases this binding. Only when the the lattice dynamics are considered in the simulation, can the experimental diffusion constants be reproduced.

    27. Organocatalytic One-Pot Asymmetric Synthesis of Functionalized Tricyclic Carbon Frameworks from a Triple-Cascade/Diels–Alder Sequence (pages 467–469)

      Dieter Enders, Matthias R. M. Hüttl, Jan Runsink, Gerhard Raabe and Bianca Wendt

      Article first published online: 8 DEC 2006 | DOI: 10.1002/anie.200603434

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      Hitting the teens! Five C[BOND]C bonds and eight stereocenters were formed in a one-pot asymmetric multicomponent domino reaction, which led to the functionalized tricyclic diterpenoid-type core structures (see scheme, IMDA=intramolecular Diels–Alder reaction).

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    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Review
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    10. Preview
    1. You have free access to this content
      Preview: Angew. Chem. Int. Ed. 4/2007 (page 473)

      Article first published online: 27 DEC 2006 | DOI: 10.1002/anie.200690177

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