Bismuth Complexes Inhibit the SARS Coronavirus (pages 6464–6468)
Nan Yang, Julian A. Tanner, Bo-Jian Zheng, Rory M. Watt, Ming-Liang He, Lin-Yu Lu, Jie-Qing Jiang, Ka-To Shum, Yong-Ping Lin, Kin-Ling Wong, Marie C. M. Lin, Hsiang-Fu Kung, Hongzhe Sun and Jian-Dong Huang
Version of Record online: 23 JUL 2007 | DOI: 10.1002/anie.200701021
Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss=single-stranded DNA, ds=duplex DNA.