Cleavage Agents for Soluble Oligomers of Amyloid β Peptides (pages 7064–7067)
Junghun Suh, Sang Ho Yoo, Min Gyum Kim, Keunhong Jeong, Jae Young Ahn, Myoung-soon Kim, Pil Seok Chae, Tae Yeon Lee, Jaehwa Lee, Jeongkuk Lee, Yun Ah Jang and Eun Hwa Ko
Version of Record online: 20 AUG 2007 | DOI: 10.1002/anie.200702399
Clearing the mind: Peptide-cleaving agents for amyloid β-42 (Aβ42) oligomers (see scheme), the intermediate neurotoxic species in the pathology of Alzheimer's disease, have been obtained from a combinatorial library built using the CoIII complex of 1,4,7,10-tetraazacyclododecane as the reaction center. Effective cleavage of the Aβ42 oligomers occurs at submicromolar concentrations of the agents.