Total Synthesis of Rapamycin (pages 591–597)
Matthew L. Maddess, Miles N. Tackett, Hidenori Watanabe, Paul E. Brennan, Christopher D. Spilling, James S. Scott, David P. Osborn and Steven V. Ley
Version of Record online: 8 DEC 2006 | DOI: 10.1002/anie.200604053
Rapamycin synthesis all wrapped up: A new convergent synthesis of rapamycin (1) is reported that involves a macroetherification/catechol tethering strategy for construction of the macrocyclic core of this intriguing natural product. Other studies on this commercialized potent immunosuppressant delineate new cell signaling pathways of relevance to cancer chemotherapy.