Angewandte Chemie International Edition

Cover image for Vol. 46 Issue 7

February 5, 2007

Volume 46, Issue 7

Pages 991–1187

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Book Reviews
    8. Highlight
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Cover Picture: The Exciting Chemistry of Tetraazidomethane (Angew. Chem. Int. Ed. 7/2007) (page 991)

      Klaus Banert, Young-Hyuk Joo, Tobias Rüffer, Bernhard Walfort and Heinrich Lang

      Article first published online: 29 JAN 2007 | DOI: 10.1002/anie.200790019

      Not only as an explosive but also in its sometimes surprising reactions, tetraazidomethane proves to be an exciting substance. As shown in the cover picture, the compound can be synthesized from commercially available trichloroacetonitrile in one step, isolated by preparative gas chromatography as a limpid liquid, and characterized by its 15N NMR spectrum measured with natural isotopic abundance. Although a simple trapping product is formed in the presence of cyclooctyne, tetraazidomethane undergoes a more complex transformation with norbornene. Further reactions are described by K. Banert et al. in their Communication on page 1168 ff.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Book Reviews
    8. Highlight
    9. Minireview
    10. Review
    11. Communications
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    1. Inside Cover: NMR Study of Water Molecules Confined in Extended Nanospaces (Angew. Chem. Int. Ed. 7/2007) (page 992)

      Takehiko Tsukahara, Akihide Hibara, Yasuhisa Ikeda and Takehiko Kitamori

      Article first published online: 29 JAN 2007 | DOI: 10.1002/anie.200790020

      In confined spaces water shows unique properties that are not seen on the bulk scale. In their Communication on page 1180ff., T. Kitamori and co-workers describe the local structural and dynamic properties of water confined in spaces extending from tens to several hundreds of nanometers on a glass chip. NMR data is used to propose a model for the interfacial phase consisting of loosely coupled water molecules between the surface and the bulk (see picture). The results are important for implementing micro- and nanofluidic devices on a chip.

  3. Graphical Abstract

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    1. Graphical Abstract: Angew. Chem. Int. Ed. 7/2007 (pages 995–1004)

      Article first published online: 29 JAN 2007 | DOI: 10.1002/anie.200790021

  4. Corrigendum

    1. Top of page
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    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
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    8. Highlight
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      Synthesis of the Southern FGHI Ring System of Azaspiracid-1 and Investigation into the Controlling Elements of C28- and C36-Ketalization (page 1004)

      Xiao-Ti Zhou, Liang Lu, Daniel P. Furkert, Charles E. Wells and Rich G. Carter

      Article first published online: 29 JAN 2007 | DOI: 10.1002/anie.200790017

      This article corrects:
  5. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Book Reviews
    8. Highlight
    9. Minireview
    10. Review
    11. Communications
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  6. Book Reviews

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    1. Kinetics of Catalytic Reactions. By M. Albert Vannice. (page 1007)

      Panagiotis G. Smirniotis

      Article first published online: 29 JAN 2007 | DOI: 10.1002/anie.200585417

  7. Highlight

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    1. Cleavable Dendrimers (pages 1010–1017)

      Marc Gingras, Jean-Manuel Raimundo and Yoann M. Chabre

      Article first published online: 29 DEC 2006 | DOI: 10.1002/anie.200601962

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      Breaking up is not hard to do: There has been great interest in the synthesis of dendrimers, but their degradability or disassembly has been less-well studied. A summary of the most recent developments in the disassemby of cleavable dendrimers by dissociation of covalent bonds (see picture) is given in this Highlight. This emerging field has already made a fundamental impact on drug delivery, nanomedecine (oncology), and materials science.

  8. Minireview

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    1. 1,3-Dipolar Cycloadditions of Azides and Alkynes: A Universal Ligation Tool in Polymer and Materials Science (pages 1018–1025)

      Jean-François Lutz

      Article first published online: 9 JAN 2007 | DOI: 10.1002/anie.200604050

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      Clicking into place: Within the last two years, the synthetic concept of “click” chemistry proposed by Sharpless has become tremendously popular in material science. In particular, the copper-catalyzed click 1,3-dipolar cycloaddition of azides and alkynes has been extensively explored in the fields of polymer chemistry, biotechnology, and nanoscience.

  9. Review

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    1. Insulated Molecular Wires (pages 1028–1064)

      Michael J. Frampton and Harry L. Anderson

      Article first published online: 16 JAN 2007 | DOI: 10.1002/anie.200601780

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      Plastic nanoelectronics! Threading a molecular organic semiconductor inside an insulating sheath (see example) provides control of properties such as luminescence, electrical transport, and chemical stability. Applications in electroluminescent displays, sensors, and hydrogen generators are now within reach.

  10. Communications

    1. Top of page
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    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Book Reviews
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    9. Minireview
    10. Review
    11. Communications
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    1. The Total Synthesis of the Oxopolyene Macrolide RK-397 (pages 1066–1070)

      Mark J. Mitton-Fry, Aaron J. Cullen and Tarek Sammakia

      Article first published online: 18 OCT 2006 | DOI: 10.1002/anie.200602601

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      It works both ways: The convergent total synthesis of the oxopolyene macrolide RK-397 utilizes remote asymmetric induction and a two-directional chain synthesis to prepare the polyol portion of the molecule, as well as a cross-metathesis reaction of a trienal with a terminal alkene to append the polyene to the polyol.

    2. Superstructure Formation and Rearrangement in the Adlayer of a Rare-Earth-Metal Triple-Decker Sandwich Complex at the Electrochemical Interface (pages 1071–1074)

      Soichiro Yoshimoto, Takahiro Sawaguchi, Wei Su, Jianzhuang Jiang and Nagao Kobayashi

      Article first published online: 29 DEC 2006 | DOI: 10.1002/anie.200603585

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      Sense of direction: A characteristic well-ordered domain of a 2:1 sandwich complex consisting of phthalocyanines and tetraphenylporphyrin was observed on an Au(111) surface by STM in situ, indicating that a highly ordered array was formed by alternately arranging the molecules in two different orientations.

    3. Heterogeneous Asymmetric Catalysis with Homochiral Metal–Organic Frameworks: Network-Structure-Dependent Catalytic Activity (pages 1075–1078)

      Chuan-De Wu and Wenbin Lin

      Article first published online: 20 DEC 2006 | DOI: 10.1002/anie.200602099

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      It's all in the preparation: Heterogeneous asymmetric catalysts based on two homochiral highly porous metal–organic frameworks formed from the same building blocks show remarkably different activity. Although both catalysts are based on twofold interpenetrated structures, one catalyzes the addition of diethylzinc to aromatic aldehydes with high enantioselectivity (up to 90 % ee), while the other is inactive.

    4. Solid-State NMR Spectroscopy of a Paramagnetic Protein: Assignment and Study of Human Dimeric Oxidized CuII–ZnII Superoxide Dismutase (SOD) (pages 1079–1082)

      Guido Pintacuda, Nicolas Giraud, Roberta Pierattelli, Anja Böckmann, Ivano Bertini and Lyndon Emsley

      Article first published online: 27 DEC 2006 | DOI: 10.1002/anie.200603093

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      A solid story: The paramagnetic form of the protein superoxide dismutase (SOD; see portion of structure in upper right corner of picture with detectability sphere in blue) is shown to be accessible to high-resolution solid-state magic angle spinning NMR studies when in microcrystalline form. A nearly complete assignment of the signals of this 32-kDa dimer has been achieved (13C–15N NMR correlation spectrum shown in background).

    5. Nanometer-Sized Shell Molecules That Confine Endohedral Polymerizing Units (pages 1083–1085)

      Takashi Murase, Sota Sato and Makoto Fujita

      Article first published online: 5 JAN 2007 | DOI: 10.1002/anie.200603561

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      Polymerization in a nutshell: A discrete spherical Pd12L24 complex was prepared that confines 24 tethered methyl methacrylate (MMA) units internally (see picture; shell blue, Pd yellow, O red, C gray; MMA shown as space-filling representation). Endohedral radical polymerization of the monomer proceeds efficiently as a result of the high concentration of MMA units within the restricted space of the core (inner diameter: 3.7 nm).

    6. Cyclic [5]Paraphenyleneacetylene: Synthesis, Properties, and Formation of a Ring-in-Ring Complex Showing a Considerably Large Association Constant and Entropy Effect (pages 1086–1088)

      Takeshi Kawase, Yoshitaka Nishiyama, Takamitsu Nakamura, Takahiro Ebi, Kouzou Matsumoto, Hiroyuki Kurata and Masaji Oda

      Article first published online: 20 DEC 2006 | DOI: 10.1002/anie.200603707

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      In the ring: The title compound ([5]CPPA), the smallest belt-shaped conjugated system known to date, forms a considerably stable ring-in-ring complex with [8]CPPA (see picture). [8]CPPA⊃[5]CPPA has a smaller contact area than [9]CPPA⊃[6]CPPA but its large Ka and ΔH values reveal that the interaction results from the electrostatic attractive force rather than the dispersion force.

    7. Formation of Mesoporous Carbon With a Face-Centered-Cubic Fdequation imagem Structure and Bimodal Architectural Pores From the Reverse Amphiphilic Triblock Copolymer PPO-PEO-PPO (pages 1089–1093)

      Yan Huang, Huaqiang Cai, Ting Yu, Fuqiang Zhang, Fan Zhang, Yan Meng, Dong Gu, Ying Wan, Xiuli Sun, Bo Tu and Dongyuan Zhao

      Article first published online: 20 DEC 2006 | DOI: 10.1002/anie.200603665

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      From polymer templates to mesoporous materials: With the reverse amphiphilic triblock copolymer PPO-PEO-PPO and a resol resin precursor an organic–organic self-assembly process leads to the formation of an ordered polymer and a carbon mesostructure with a face-centered-cubic Fdequation imagem symmetry and bimodal pores (see scheme). PPO=polypropylenoxide, PEO=polyethylenoxide.

    8. A Method for Patterning Multiple Types of Cells by Using Electrochemical Desorption of Self-Assembled Monolayers within Microfluidic Channels (pages 1094–1096)

      Yong Li, Bo Yuan, Hang Ji, Dong Han, Shiqian Chen, Feng Tian and Xingyu Jiang

      Article first published online: 21 DEC 2006 | DOI: 10.1002/anie.200603844

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      Fenced in: Selective electrochemical desorption of self-assembled monolayers of HS(CH2)11(OCH2CH2)6OH was carried out on parts of a gold substrate restricted to microfluidic channels. This chemical transformation activates parts of the surface for adhesion of multiple types of cells with well-controlled geometry.

    9. All-Carbon Quaternary Stereogenic Centers by Enantioselective Cu-Catalyzed Conjugate Additions Promoted by a Chiral N-Heterocyclic Carbene (pages 1097–1100)

      M. Kevin Brown, Tricia L. May, Carl A. Baxter and Amir H. Hoveyda

      Article first published online: 3 JAN 2007 | DOI: 10.1002/anie.200604511

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      Necessity is the mother of invention: When the available catalysts do not cut it, a new one has to be developed. A chiral N-heterocyclic carbene (NHC) is used in the first catalytic asymmetric conjugate addition of alkyl- and arylzinc reagents to γ-keto esters (see scheme).

    10. A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction (pages 1101–1104)

      Armando Carlone, Silvia Cabrera, Mauro Marigo and Karl Anker Jørgensen

      Article first published online: 29 DEC 2006 | DOI: 10.1002/anie.200604479

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      As easy as pouring! Three C[BOND]C bonds, up to three stereocenters, and ee values greater than 97 % are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS=trimethylsilyl; EWG=electron-withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user-friendly reaction conditions are key features of this transformation.

    11. Alkali-Metal-Mediated Manganation: A Method for Directly Attaching Manganese(II) Centers to Aromatic Frameworks (pages 1105–1108)

      Joaquin Garcia-Álvarez, Alan R. Kennedy, Jan Klett and Robert E. Mulvey

      Article first published online: 29 DEC 2006 | DOI: 10.1002/anie.200604542

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      Magic Metalation: Inert towards conventional organomanganese reagents, ferrocene can now be directly manganated by using a specially designed mixed lithium/manganese(II) mixed dialkyl/amido reagent. The picture shows the structure of a dimanganese compound with three manganated 1,1′-ferrocenediyl fragments.

    12. Highly Efficient, Near-Infrared Electrophosphorescence from a Pt–Metalloporphyrin Complex (pages 1109–1112)

      Carsten Borek, Kenneth Hanson, Peter I. Djurovich, Mark E. Thompson, Kristen Aznavour, Robert Bau, Yiru Sun, Stephen R. Forrest, Jason Brooks, Lech Michalski and Julie Brown

      Article first published online: 9 JAN 2007 | DOI: 10.1002/anie.200604240

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      Red-shifting beyond red: The nonplanar porphyrin complex [Pt(tpbp)] (tpbp=tetraphenyltetrabenzoporphyrin) has been used as a phosphorescent dopant in highly efficient electrophosphorescent devices that emit in the near-infrared region (see normalized emission spectrum). The high efficiencies of these NIR devices make them amenable to many night-vision display and sensing applications.

    13. In Situ High-Energy Synchrotron Radiation Study of Sol–Gel Nanoparticle Formation in Supercritical Fluids (pages 1113–1116)

      Henrik Jensen, Martin Bremholm, Rudi P. Nielsen, Karsten D. Joensen, Jan S. Pedersen, Henrik Birkedal, Yu-Sheng Chen, Jon Almer, Erik G. Søgaard, Steen B. Iversen and Bo B. Iversen

      Article first published online: 4 JAN 2007 | DOI: 10.1002/anie.200603386

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      Sol–gel chemistry can be performed in minutes instead of hours in a supercritical fluid, a process that has now been monitored in situ by a combination of small- and wide-angle X-ray scattering (SAXS and WAXS) with high-energy synchrotron radiation. The setup used to monitor the growth of TiO2 nanoparticles, seeded by polypropylene fibers, in supercritical CO2 is shown schematically in the picture.

    14. Gold(I)-Catalyzed Annulation of Salicylaldehydes and Aryl Acetylenes as an Expedient Route to Isoflavanones (pages 1117–1119)

      Rachid Skouta and Chao-Jun Li

      Article first published online: 19 DEC 2006 | DOI: 10.1002/anie.200603495

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      The value of gold ‘n’ rings: An isoflavanone moiety is the key structural feature of many complex natural products. It is now shown that such structures can be generated efficiently and atom economically by the annulation of simple o-hydroxybenzaldehydes with alkynes in the presence of a gold(I) catalyst (see scheme).

    15. Site-Specific Recognition of Nanophase-Separated Surfaces of Amphiphilic Block Copolymers by Hydrophilic and Hydrophobic Gold Nanoparticles (pages 1120–1123)

      Shigeru Watanabe, Ryutaro Fujiwara, Masanori Hada, Yuka Okazaki and Tomokazu Iyoda

      Article first published online: 29 DEC 2006 | DOI: 10.1002/anie.200603516

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      Likes attract: Site-specific recognition of the nanophase-separated surface of a PEOm-b-PMA(Az)n film (PEO=polyethylene oxide, PMA(Az)=polymethacrylate with azobenzene-based liquid-crystalline side-chain) by hydrophilic and hydrophobic gold nanoparticles (Au NPs) was studied. The hydrophilic and hydrophobic Au NPs were found to selectively assemble on the hydrophilic PEO and hydrophobic PMA(Az) domains, respectively.

    16. Solid-State Interconversions of Coordination Networks and Hydrogen-Bonded Salts (pages 1124–1128)

      Christopher J. Adams, Howard M. Colquhoun, Paul C. Crawford, Matteo Lusi and A. Guy Orpen

      Article first published online: 27 DEC 2006 | DOI: 10.1002/anie.200603593

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      Thermal or chemical treatment of crystalline 4,4′-bipyridinium salts of [MCl4]2− (M=Co, Zn, Fe, or Pt) leads to HCl loss and formation of coordination network solids [{MCl2(4,4′-bipy)}n]. For M=Co, Zn, and Fe, these solids can also be prepared by mechanochemical means. Their exposure to HCl vapor or the mechanochemical reaction of metal dichlorides with [4,4′-H2bipy]Cl2 gives [4,4′-H2bipy]2+ salts of [CoCl4]2−, [ZnCl4]2−, and, for the first time, [FeCl4]2−.

    17. α,ω-Functionalized 2,4-Dimethylpentane Dyads and 2,4,6-Trimethylheptane Triads through Asymmetric Hydrogenation (pages 1129–1131)

      Jianguang Zhou and Kevin Burgess

      Article first published online: 3 JAN 2007 | DOI: 10.1002/anie.200603635

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      A match made in heaven: All the possible stereoisomers of α,ω-functionalized 2,4-dimethylpentane dyad and 2,4,6-trimethylheptane triad chirons (see picture; A and B, respectively; FG=functional group, PG=protecting group) can be reached by using a combination of a chiral catalyst and substrate effects in the hydrogenation of mainly nonfunctionalized alkenes. Excellent diastereo- and enantioselectivities were achieved.

    18. Total Synthesis and Determination of the Absolute Configuration of (+)-Intricatetraol (pages 1132–1135)

      Yoshiki Morimoto, Tatsuya Okita, Mamoru Takaishi and Takeshi Tanaka

      Article first published online: 27 DEC 2006 | DOI: 10.1002/anie.200603806

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      A victory for synthesis: The total synthesis of the marine triterpene polyether (+)-intricatetraol (1) has revealed its absolute configuration, which could not be determined even by spectroscopic methods. The approach features the enantioselective construction of the unique vicinal bromochloro functionality and an efficient olefin-metathesis strategy that takes the C2 symmetry of the target into consideration.

    19. Crystal Structures of and Displacive Transitions in OsN2, IrN2, RuN2, and RhN2 (pages 1136–1140)

      Rong Yu, Qian Zhan and Lutgard C. De Jonghe

      Article first published online: 20 DEC 2006 | DOI: 10.1002/anie.200604151

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      Unexpected crystal structures: The noble-metal pernitrides OsN2 and IrN2 are found to adopt structure types never before observed in nitrides (see picture; Os/Ir blue, N green). Furthermore, the crystal structures of RuN2 and RhN2, which have yet to be synthesized, are predicted. A pressure-induced displacive phase transition and a semiconductor–metal transition are predicted for IrN2.

    20. Gold(I)-Catalyzed 5-endo Hydroxy- and Alkoxycyclization of 1,5-Enynes: Efficient Access to Functionalized Cyclopentenes (pages 1141–1144)

      Andrea K. Buzas, Florin M. Istrate and Fabien Gagosz

      Article first published online: 13 DEC 2006 | DOI: 10.1002/anie.200604140

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      The rapid and stereoselective construction of highly functionalized cyclopentenes is possible through gold(I)-catalyzed 5-endo hydroxy- and methoxycyclizations of 1,5-enynes. More complex 5,7- and 5,8-fused bicyclic structures of a type found in many terpene natural products can be formed by combining the cyclization reaction with ring-closing metathesis (RCM; see scheme).

    21. Solvation-Controlled Luminescence of SmII Complexes (pages 1145–1148)

      Joseph A. Teprovich Jr., Edamana Prasad and Robert A. Flowers II

      Article first published online: 19 DEC 2006 | DOI: 10.1002/anie.200604100

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      The jewel in the crown: Addition of a crown ether to SmI2 in acetonitrile produces a complex that insulates the SmII ion from interaction with solvent and substrates. Consequently, solvent-induced luminescence quenching is decreased, leading to a significantly increased excited-state lifetime. Thus, it is possible to generate highly stable and luminescent LnII complexes in solution through proper choice of ligand and solvent.

    22. Triphenylamine-Dendronized Pure Red Iridium Phosphors with Superior OLED Efficiency/Color Purity Trade-Offs (pages 1149–1151)

      Guijiang Zhou, Wai-Yeung Wong, Bing Yao, Zhiyuan Xie and Lixiang Wang

      Article first published online: 3 JAN 2007 | DOI: 10.1002/anie.200604094

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      As good as red: Highly efficient pure red OLEDs based on iridium electrophosphors functionalized with hole-transporting triphenylamine dendrons are prepared (see picture). These bifunctional dendrimers give a peak efficiency of 11.7 % with an excellent color quality and offer an attractive avenue for the development of metal phosphors with the optimized efficiency/color purity trade-offs required for pure red-emitting devices. OLED=organic light-emitting diode.

    23. Near-Monodisperse Tetrahedral Rhodium Nanoparticles on Charcoal: The Shape-Dependent Catalytic Hydrogenation of Arenes (pages 1152–1155)

      Kang Hyun Park, Kwonho Jang, Hae Jin Kim and Seung Uk Son

      Article first published online: 21 DEC 2006 | DOI: 10.1002/anie.200603961

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      The shape of things to come? Monodisperse (4.9±0.4)-nm tetrahedral rhodium nanoparticles on charcoal (▴/C) are compared to (4.8±0.4)-nm spherical rhodium nanoparticles on charcoal (•/C) and commercial Rh/C as a catalyst for the hydrogenation of anthracene (see picture). The former is 5.8- and 109-times more active than the latter two, respectively. It also shows a higher selectivity and excellent activity in the hydrogenation of several other arenes.

    24. Stable Mononuclear Lead(III) Compound: A Lead-Centered Radical (pages 1156–1159)

      Christoph Förster, Karl W. Klinkhammer, Boris Tumanskii, Hans-Jörg Krüger and Harald Kelm

      Article first published online: 15 DEC 2006 | DOI: 10.1002/anie.200603323

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      Plumb radical: The kinetically stable plumbyl radical Pb[SiEt(SiMe3)2]3 (see molecular structure; red Pb, light purple Si, dark purple C) was obtained through oxidation of Pb[SiEt(SiMe3)2]3 ions. With a half-life of about 8.5 hours at room temperature, it cleanly decomposes to elementary lead and Pb[SiEt(SiMe3)2]4.

    25. Variable Synthesis of the Optically Active Thiotetronic Acid Antibiotics Thiolactomycin, Thiotetromycin, and 834-B1 (pages 1160–1163)

      Korinna L. Dormann and Reinhard Brückner

      Article first published online: 20 DEC 2006 | DOI: 10.1002/anie.200603562

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      In seven steps: The antibiotic (+)-thiolactomycin was synthesized in seven steps and with 16 % overall yield from 4-acetoxy-2-methyl-2-buten-1-al, an intermediate of the industrial synthesis of vitamin A. Key transformations were the catalytic asymmetric Sharpless epoxidation of an ethoxycarbonyl-substituted pentadienol (93 % ee) and a regio- and stereoselective thiolysis of the resulting epoxide (see scheme).

    26. With Phosphinophosphonic Acids to Nanostructured, Water-Soluble, and Catalytically Active Rhodium Clusters (pages 1164–1167)

      Julija Glöckler, Stefan Klützke, Wolfgang Meyer-Zaika, Armin Reller, F. Javier García-García, Hans-Henning Strehblow, Petra Keller, Eva Rentschler and Wolfgang Kläui

      Article first published online: 27 DEC 2006 | DOI: 10.1002/anie.200603402

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      Pressure-sized clusters: Aqueous solutions of rhodium complexes stabilized by phosphinophosphonic acid ligands turn ink-black under a hydrogen atmosphere. Depending on the hydrogen pressure applied, rhodium clusters of 2–6 nm can be isolated (see scheme). These clusters are catalysts for the biphasic hydrogenation of olefins, arenes, and nitro compounds.

    27. The Exciting Chemistry of Tetraazidomethane (pages 1168–1171)

      Klaus Banert, Young-Hyuk Joo, Tobias Rüffer, Bernhard Walfort and Heinrich Lang

      Article first published online: 4 DEC 2006 | DOI: 10.1002/anie.200603960

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      With a nitrogen content of 93.3 %, “perazidomethane” (CN12) is highly explosive but nevertheless isolable. The title compound, which is accessible from commercially available trichloroacetonitrile in one step, undergoes simple dissociation and trapping reactions as well as more-complex transformations (for example, in the presence of norbornene; see scheme).

    28. Engineering the Structural Properties of DNA Block Copolymer Micelles by Molecular Recognition (pages 1172–1175)

      Ke Ding, Fikri E. Alemdaroglu, Michael Börsch, Rüdiger Berger and Andreas Herrmann

      Article first published online: 9 JAN 2007 | DOI: 10.1002/anie.200603064

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      Transforming micelle structure: Amphiphilic DNA block copolymers form spherical micelles in solution. They can be transformed into rodlike micelles by hybridization with long DNA sequences, which consist of parallel aligned double-stranded DNA molecules “glued” together by hydrophobic interactions of the organic polymer (see picture). The template determines the length of the rodlike aggregates.

    29. Fast High-Resolution Protein Structure Determination by Using Unassigned NMR Data (pages 1176–1179)

      Jegannath Korukottu, Monika Bayrhuber, Pierre Montaville, Vinesh Vijayan, Young-Sang Jung, Stefan Becker and Markus Zweckstetter

      Article first published online: 5 JAN 2007 | DOI: 10.1002/anie.200603213

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      The major bottleneck of rapid NMR-based structure determination is data analysis. The solution to this problem is a method that enables automatic high-resolution protein-structure determination from unassigned, experimental NMR data without manual intervention in less than 24 h.

    30. NMR Study of Water Molecules Confined in Extended Nanospaces (pages 1180–1183)

      Takehiko Tsukahara, Akihide Hibara, Yasuhisa Ikeda and Takehiko Kitamori

      Article first published online: 29 JAN 2007 | DOI: 10.1002/anie.200604502

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      Does water suffer from claustrophobia? The local structural and dynamic properties of water in confined (300–4000 nm) spaces were characterized by an NMR study of the size-dependent relaxation phenomena, which in turn reflect changes in water mobility and proton transfer. The results are important for understanding fluidics in extended nanospaces and in implementing micro-/nanofluidic devices.

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    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Book Reviews
    8. Highlight
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    10. Review
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      Preview: Angew. Chem. Int. Ed. 8/2007 (page 1187)

      Article first published online: 29 JAN 2007 | DOI: 10.1002/anie.200790018

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